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Pinacidil Side Effects

The most commonly reported side effects of pinacidil include rash, fatigue, and thoracic vertebral fracture, based on 68 FDA adverse event reports from 2004 to 2024. 5.9% of reports found the drug to be ineffective.

Pinacidil side effects

Percentages show how often each reaction appears relative to total reports for pinacidil.

1
Rash8.8%6
2
Fatigue8.8%6
3
Thoracic Vertebral Fracture8.8%6
4
Drug Reaction With Eosinophilia And Systemic Symptoms8.8%6
5
Drug Interaction5.9%4
6
Renal Failure5.9%4
7
Vomiting5.9%4
8
Condition Aggravated5.9%4
9
Drug Ineffective5.9%4
10
Nausea5.9%4
11
Dyspnoea4.4%3
12
Diarrhoea4.4%3
13
Ankylosing Spondylitis4.4%3
14
Back Pain4.4%3
15
Pyrexia4.4%3

These are voluntary reports and do not establish that pinacidil caused these reactions.

Report severity

95.6%Serious65 reports
60.3%Hospitalizations41 reports
14.7%Fatal10 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pinacidil drug interactions

Other drugs that appear in adverse event reports alongside pinacidil. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Etanercept17.6%12
2
Infliximab14.7%10
3
Gabapentin8.8%6
4
Denosumab8.8%6
5
Adalimumab7.4%5
6
Acyclovir7.4%5
7
Bevacizumab4.4%3
8
Carboplatin4.4%3
9
Methotrexate2.9%2
10
Pregabalin2.9%2
11
Temsirolimus2.9%2
12
Rituximab2.9%2
13
Dabigatran-etexilate-mesylate2.9%2
14
Canakinumab2.9%2
15
Atezolizumab2.9%2

Taken alongside

1
Omeprazole47.1%32
2
Methotrexate17.6%12
3
Calcium11.8%8
4
Amlodipine10.3%7
5
Teriparatide10.3%7
6
Acetaminophen10.3%7
7
Ergocalciferol10.3%7
8
Prednisone8.8%6
9
Lacosamide8.8%6
10
Alendronate-sodium8.8%6
11
Esomeprazole5.9%4
12
Ibuprofen4.4%3
13
Tramadol-hydrochloride4.4%3
14
Hydrocortisone4.4%3
15
Diphenhydramine4.4%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pinacidil side effects

33.8% of pinacidil adverse event reports involve female patients and 63.2% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.8%
Male63.2%
Unknown2.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6472.7%
65+27.3%

What is pinacidil used for

Conditions and purposes for which patients were taking pinacidil when the adverse event was reported.

Ankylosing SpondylitisAntiinflammatory TherapyArthritisAnalgesic TherapyDrug Use For Unknown IndicationGastric DilatationHypertensionInflammationPainPolymyositisProduct Used For Unknown IndicationProphylaxisPulmonary HypertensionRheumatoid ArthritisRheumatoid Arthritis

Showing 15 of 16 indications

Pinacidil brand names and reporting trend

Pinacidil is sold under the brand name Pindac.

Brand names

Pindac70

Quarterly reports (20042024)

200420102024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pinacidil with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.