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Phytonadione Side Effects

The most commonly reported side effects of phytonadione include sepsis, nausea, and off label use, based on 3,692 FDA adverse event reports from 2004 to 2025.

Phytonadione side effects

Percentages show how often each reaction appears relative to total reports for phytonadione.

1
Sepsis8.7%323
2
Nausea8.7%321
3
Off Label Use8.6%316
4
Vomiting8.0%297
5
Abdominal Distension7.4%274
6
Abdominal Pain7.2%266
7
Ascites7.2%265
8
Constipation7.0%258
9
Multiple Organ Dysfunction Syndrome7.0%257
10
General Physical Health Deterioration6.8%250
11
Hyponatraemia6.8%250
12
Stress6.0%221
13
Cardiogenic Shock6.0%220
14
Appendicitis5.8%215
15
Appendicolith5.8%213

These are voluntary reports and do not establish that phytonadione caused these reactions.

Report severity

90.7%Serious3,349 reports
58.7%Hospitalizations2,167 reports
27.1%Fatal999 reports

Seriousness is determined by the reporter, not by OpenClaim.

Phytonadione drug interactions

Other drugs that appear in adverse event reports alongside phytonadione. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ivacaftor11.5%426
2
Acetaminophen9.7%359
3
Heparin9.4%346
4
Ceftriaxone-sodium9.1%337
5
Metronidazole8.8%324
6
Warfarin8.3%308
7
Ondansetron8.1%298
8
Lansoprazole8.0%297
9
Insulin8.0%295
10
Albuterol7.9%291
11
Simvastatin7.8%288
12
Dalteparin-sodium7.7%285
13
Dobutamine-hydrochloride7.7%284
14
Hydromorphone-hydrochloride7.6%279
15
Ipratropium-bromide7.4%273

Taken alongside

1
Albuterol23.1%852
2
Acetaminophen21.9%808
3
Furosemide18.6%685
4
Sodium-chloride17.2%636
5
Lipase17.2%635
6
Ondansetron16.8%622
7
Pantoprazole-sodium16.8%621
8
Ergocalciferol16.5%611
9
Pancrelipase-amylase15.9%586
10
Protease15.8%585
11
Omeprazole15.0%552
12
Potassium-chloride13.8%508
13
Azithromycin13.7%504
14
Dornase-alfa13.6%503
15
Insulin13.1%482

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports phytonadione side effects

42.0% of phytonadione adverse event reports involve female patients and 51.9% involve male patients. The largest age group is adult at 46%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.0%
Male51.9%
Unknown6.2%

Age group

< 23.6%
2–116.2%
12–177.6%
18–6445.7%
65+36.8%

What is phytonadione used for

Conditions and purposes for which patients were taking phytonadione when the adverse event was reported.

Activated Partial Thromboplastin Time ProlongedAcute Hepatic FailureAdverse EventAmyloidosisAnaemiaAnal HaemorrhageAngina PectorisAnticoagulant TherapyAnticoagulation Drug Level Above TherapeuticAspiration Pleural CavityAtrial FibrillationAbdominal SepsisAcidosisActivated Partial Thromboplastin Time ShortenedAcute Hepatic Failure

Showing 15 of 193 indications

Phytonadione brand names and reporting trend

Phytonadione is sold under the brand name Konakion.

Brand names

Konakion3,274

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking phytonadione with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.