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Phentolamine Side Effects

The most commonly reported side effects of phentolamine include hypotension, blood glucose increased, and ocular hyperaemia, based on 333 FDA adverse event reports from 2004 to 2025. 6.3% of reports found the drug to be ineffective.

Phentolamine side effects

Percentages show how often each reaction appears relative to total reports for phentolamine.

1
Drug Ineffective6.3%21
2
Hypotension6.0%20
3
Blood Glucose Increased5.1%17
4
Ocular Hyperaemia5.1%17
5
Blood Urea Increased4.8%16
6
Neutrophil Count Increased4.5%15
7
Lymphocyte Count Decreased4.2%14
8
Headache3.9%13
9
Off Label Use3.9%13
10
Diarrhoea3.9%13
11
Blood Pressure Increased3.6%12
12
Anaemia3.6%12
13
Dyspnoea3.3%11
14
Haemoglobin Decreased3.3%11
15
Tachycardia3.0%10

These are voluntary reports and do not establish that phentolamine caused these reactions.

Report severity

79.0%Serious263 reports
34.2%Hospitalizations114 reports
8.7%Fatal29 reports

Seriousness is determined by the reporter, not by OpenClaim.

Phentolamine drug interactions

Other drugs that appear in adverse event reports alongside phentolamine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Mycophenolate7.5%25
2
Basiliximab7.2%24
3
Methylprednisolone6.9%23
4
Prednisone6.6%22
5
Tacrolimus5.7%19
6
Ethinyl-estradiol5.4%18
7
Desogestrel4.8%16
8
Furosemide3.9%13
9
Epinephrine3.6%12
10
Nicardipine-hydrochloride3.6%12
11
Heparin3.6%12
12
Lenalidomide3.6%12
13
Nitroglycerin3.3%11
14
Labetalol-hydrochloride3.0%10
15
Amlodipine3.0%10

Taken alongside

1
Furosemide13.5%45
2
Insulin10.2%34
3
Amlodipine9.9%33
4
Nitroglycerin9.3%31
5
Potassium-chloride8.4%28
6
Dopamine-hydrochloride8.1%27
7
Lansoprazole7.8%26
8
Desogestrel7.8%26
9
Ethinyl-estradiol7.8%26
10
Omeprazole7.5%25
11
Metoprolol7.5%25
12
Aspirin7.2%24
13
Heparin7.2%24
14
Sodium-bicarbonate6.6%22
15
Alprostadil6.0%20

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports phentolamine side effects

35.4% of phentolamine adverse event reports involve female patients and 51.7% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.4%
Male51.7%
Unknown12.9%

Age group

< 25.7%
2–113.0%
12–171.7%
18–6469.6%
65+20.0%

What is phentolamine used for

Conditions and purposes for which patients were taking phentolamine when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAnaesthesia ReversalAnaesthesia ReversalArterial StenosisBack PainBlood Pressure AbnormalBlood Pressure FluctuationBlood Pressure IncreasedBlood Pressure MeasurementBlood Pressure Systolic IncreasedBronchitis ChronicBlood Catecholamines IncreasedBlood Pressure IncreasedBrachiocephalic Artery Stenosis

Showing 15 of 73 indications

Phentolamine brand names and reporting trend

Phentolamine is sold under the brand name Regitine.

Brand names

Regitine3

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking phentolamine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.