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Pheniramine Side Effects

The most commonly reported side effects of pheniramine include eye irritation, mydriasis, and eye pain, based on 4,008 FDA adverse event reports from 2004 to 2025. 10.7% of reports found the drug to be ineffective.

Pheniramine side effects

Percentages show how often each reaction appears relative to total reports for pheniramine.

1
Eye Irritation17.2%689
2
Drug Ineffective10.7%430
3
Mydriasis8.2%329
4
Eye Pain6.6%264
5
Mydriasis5.9%237
6
Eye Irritation5.8%232
7
Vision Blurred5.7%228
8
Ocular Hyperaemia5.4%216
9
Product Use In Unapproved Indication5.1%206
10
Therapeutic Response Unexpected3.4%137
11
Vision Blurred3.3%133
12
Off Label Use3.0%119
13
Ocular Hyperaemia2.9%116
14
Eye Pruritus2.6%105
15
Drug Ineffective2.4%96

These are voluntary reports and do not establish that pheniramine caused these reactions.

Report severity

18.2%Serious728 reports
5.0%Hospitalizations199 reports
1.1%Fatal44 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pheniramine drug interactions

Other drugs that appear in adverse event reports alongside pheniramine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Naphazoline-hydrochloride83.2%3,335
2
Bimatoprost2.4%98
3
Lenalidomide0.9%37
4
Cyclosporine0.7%30
5
Dupilumab0.7%29
6
Brimonidine-tartrate0.6%23
7
Sodium-oxybate0.6%23
8
Ketotifen-fumarate0.4%17
9
Pomalidomide0.3%12
10
Adalimumab0.3%11
11
Dexamethasone0.3%11
12
Bevacizumab0.2%10
13
Aspirin0.2%10
14
Diphenhydramine0.2%9
15
Rituximab0.2%9

Taken alongside

1
Naphazoline-hydrochloride17.1%685
2
Acetaminophen4.9%197
3
Ergocalciferol4.3%173
4
Levothyroxine-sodium3.9%156
5
Aspirin3.9%156
6
Fluticasone3.4%136
7
Omeprazole3.2%130
8
Albuterol3.1%123
9
Cetirizine-hydrochloride2.5%100
10
Calcium2.2%90
11
Atorvastatin-calcium2.2%89
12
Metoprolol2.0%80
13
Lisinopril1.9%78
14
Ibuprofen1.9%77
15
Amlodipine1.9%76

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pheniramine side effects

54.6% of pheniramine adverse event reports involve female patients and 27.2% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.6%
Male27.2%
Unknown18.2%

Age group

< 20.6%
2–111.7%
12–172.1%
18–6460.1%
65+35.5%

What is pheniramine used for

Conditions and purposes for which patients were taking pheniramine when the adverse event was reported.

Abnormal Sensation In EyeAccidental ExposureAccidental Exposure To ProductAcneAdverse Drug ReactionAdverse ReactionAllergy ProphylaxisAllergy To AnimalAnalgesic TherapyAntiallergic TherapyArthropod BiteAsthenopiaAstigmatismAccidental Exposure To ProductAge-related Macular Degeneration

Showing 15 of 164 indications

Pheniramine brand names and reporting trend

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pheniramine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.