OpenClaim

Phenindione Side Effects

The most commonly reported side effects of phenindione include anxiety, burning sensation, and malaise, based on 21 FDA adverse event reports from 2006 to 2025.

Phenindione side effects

Percentages show how often each reaction appears relative to total reports for phenindione.

1
Anxiety33.3%7
2
Burning Sensation33.3%7
3
Malaise33.3%7
4
Unresponsive To Stimuli33.3%7
5
Death33.3%7
6
Circulatory Collapse33.3%7
7
Rash Generalised33.3%7
8
Hypotension33.3%7
9
Echocardiogram Abnormal33.3%7
10
Tachycardia28.6%6
11
Documented Hypersensitivity To Administered Drug14.3%3
12
Drug Interaction9.5%2
13
Feeding Disorder9.5%2
14
Hepatitis Cholestatic9.5%2
15
Hyporeflexia9.5%2

These are voluntary reports and do not establish that phenindione caused these reactions.

Report severity

95.2%Serious20 reports
19.0%Hospitalizations4 reports
38.1%Fatal8 reports

Seriousness is determined by the reporter, not by OpenClaim.

Phenindione drug interactions

Other drugs that appear in adverse event reports alongside phenindione. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalteparin-sodium33.3%7
2
Gemfibrozil28.6%6
3
Lenalidomide14.3%3
4
Fluoxetine-hydrochloride9.5%2
5
Tolvaptan4.8%1
6
Montelukast-sodium4.8%1
7
Warfarin4.8%1
8
Daptomycin4.8%1
9
Rituximab4.8%1
10
Pegfilgrastim4.8%1
11
Gemcitabine4.8%1
12
Cyclophosphamide4.8%1
13
Vincristine-sulfate4.8%1
14
Prednisone4.8%1
15
Dabigatran-etexilate-mesylate4.8%1

Taken alongside

1
Omeprazole42.9%9
2
Diazepam38.1%8
3
Loperamide-hydrochloride38.1%8
4
Simvastatin38.1%8
5
Mirtazapine33.3%7
6
Sotalol-hydrochloride33.3%7
7
Nifedipine33.3%7
8
Cetirizine-hydrochloride33.3%7
9
Aluminum-hydroxide33.3%7
10
Magnesium-trisilicate33.3%7
11
Folic-acid19.0%4
12
Candesartan-cilexetil19.0%4
13
Ranitidine19.0%4
14
Loratadine19.0%4
15
Levothyroxine-sodium14.3%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports phenindione side effects

61.9% of phenindione adverse event reports involve female patients and 33.3% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.9%
Male33.3%
Unknown4.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6437.5%
65+62.5%

What is phenindione used for

Conditions and purposes for which patients were taking phenindione when the adverse event was reported.

Anticoagulant TherapyDrug Use For Unknown IndicationGlomerulonephritisProduct Used For Unknown IndicationThrombosis ProphylaxisTransient Ischaemic Attack

Phenindione brand names and reporting trend

Phenindione is sold under the brand name Hedulin.

Brand names

Hedulin22

Quarterly reports (20062025)

20062025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking phenindione with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.