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Phendimetrazine Side Effects

The most commonly reported side effects of phendimetrazine include pain, toxicity to various agents, and fatigue, based on 505 FDA adverse event reports from 2004 to 2025. 5.0% of reports found the drug to be ineffective.

Phendimetrazine side effects

Percentages show how often each reaction appears relative to total reports for phendimetrazine.

1
Drug Ineffective5.0%25
2
Pain4.2%21
3
Toxicity To Various Agents4.2%21
4
Fatigue4.0%20
5
Dyspnoea3.8%19
6
Nausea3.6%18
7
Headache3.4%17
8
Sudden Cardiac Death3.4%17
9
Off Label Use3.2%16
10
Back Pain3.2%16
11
Chronic Kidney Disease3.2%16
12
Rash3.0%15
13
Asthenia2.8%14
14
Diarrhoea2.8%14
15
Arthralgia2.8%14

These are voluntary reports and do not establish that phendimetrazine caused these reactions.

Report severity

65.0%Serious328 reports
27.3%Hospitalizations138 reports
14.1%Fatal71 reports

Seriousness is determined by the reporter, not by OpenClaim.

Phendimetrazine drug interactions

Other drugs that appear in adverse event reports alongside phendimetrazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab5.7%29
2
Ethinyl-estradiol5.5%28
3
Quetiapine-fumarate5.1%26
4
Drospirenone4.6%23
5
Diphenhydramine4.4%22
6
Phentermine4.2%21
7
Bupropion3.8%19
8
Ibuprofen3.8%19
9
Esomeprazole3.6%18
10
Sodium-oxybate3.4%17
11
Lithium3.4%17
12
Lamotrigine3.2%16
13
Citalopram-hydrobromide3.2%16
14
Omeprazole3.0%15
15
Lorazepam3.0%15

Taken alongside

1
Acetaminophen17.6%89
2
Ergocalciferol11.3%57
3
Metformin9.7%49
4
Gabapentin9.5%48
5
Levothyroxine-sodium9.3%47
6
Fluticasone8.9%45
7
Aspirin8.5%43
8
Albuterol8.3%42
9
Furosemide7.9%40
10
Atorvastatin-calcium7.7%39
11
Ibuprofen7.7%39
12
Phentermine7.5%38
13
Prednisone7.3%37
14
Lorazepam7.3%37
15
Amlodipine6.9%35

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports phendimetrazine side effects

71.5% of phendimetrazine adverse event reports involve female patients and 22.2% involve male patients. The largest age group is adult at 76%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.5%
Male22.2%
Unknown6.3%

Age group

< 20.0%
2–110.0%
12–170.3%
18–6476.0%
65+23.8%

What is phendimetrazine used for

Conditions and purposes for which patients were taking phendimetrazine when the adverse event was reported.

AnorexiaAppetite DisorderAstheniaAstheniaBipolar DisorderBlood DisorderBreast Cancer MetastaticCardiovascular SymptomCholecystitisCrohn's DiseaseDecreased AppetiteDisturbance In AttentionDrug Use For Unknown IndicationDyspepsiaDecreased Appetite

Showing 15 of 50 indications

Phendimetrazine brand names and reporting trend

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking phendimetrazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.