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Pexidartinib Side Effects

The most commonly reported side effects of pexidartinib include fatigue, product dose omission issue, and hair colour changes, based on 986 FDA adverse event reports from 2015 to 2025.

Pexidartinib side effects

Percentages show how often each reaction appears relative to total reports for pexidartinib.

1
Fatigue38.4%379
2
Product Dose Omission Issue34.2%337
3
Hair Colour Changes33.6%331
4
Nausea21.6%213
5
Pruritus19.2%189
6
Aspartate Aminotransferase Increased13.8%136
7
Off Label Use13.7%135
8
Rash13.4%132
9
Alanine Aminotransferase Increased12.7%125
10
Diarrhoea10.8%106
11
Headache10.5%104
12
Pain10.2%101
13
Arthralgia9.7%96
14
Therapy Cessation8.9%88
15
Product Dose Omission In Error8.9%88

These are voluntary reports and do not establish that pexidartinib caused these reactions.

Report severity

24.7%Serious244 reports
9.6%Hospitalizations95 reports
1.8%Fatal18 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pexidartinib drug interactions

Other drugs that appear in adverse event reports alongside pexidartinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel0.5%5
2
Vimseltinib0.3%3
3
Prasugrel-hydrochloride0.1%1
4
Temozolomide0.1%1
5
Lenalidomide0.1%1
6
Oxycodone0.1%1
7
Norethindrone0.1%1
8
Sirolimus0.1%1
9
Prednisone0.1%1
10
Binimetinib0.1%1
11
Fluoxetine-hydrochloride0.1%1
12
Mometasone-furoate0.1%1
13
Ruxolitinib0.1%1
14
Treprostinil0.1%1
15
Prochlorperazine0.1%1

Taken alongside

1
Ondansetron3.9%38
2
Ergocalciferol3.3%33
3
Acetaminophen3.1%31
4
Amlodipine2.7%27
5
Ibuprofen2.7%27
6
Levothyroxine-sodium2.2%22
7
Aspirin1.9%19
8
Oxycodone1.8%18
9
Famotidine1.8%18
10
Gabapentin1.6%16
11
Ascorbic-acid1.4%14
12
Cetirizine-hydrochloride1.4%14
13
Hydrochlorothiazide1.4%14
14
Losartan-potassium1.4%14
15
Atorvastatin-calcium1.3%13

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pexidartinib side effects

55.6% of pexidartinib adverse event reports involve female patients and 33.8% involve male patients. The largest age group is adult at 84%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.6%
Male33.8%
Unknown10.6%

Age group

< 20.0%
2–110.3%
12–174.6%
18–6484.4%
65+10.7%

What is pexidartinib used for

Conditions and purposes for which patients were taking pexidartinib when the adverse event was reported.

Amyotrophic Lateral SclerosisArthralgiaArthropathyBone Giant Cell TumourBone Giant Cell Tumour BenignBone Giant Cell Tumour MalignantBone NeoplasmBrain Neoplasm MalignantBreast CancerBenign Bone NeoplasmBenign Connective Tissue NeoplasmBenign NeoplasmBone Giant Cell TumourBone Giant Cell Tumour BenignBone Neoplasm

Showing 15 of 87 indications

Pexidartinib brand names and reporting trend

Pexidartinib is sold under the brand name Turalio.

Brand names

Turalio681

Quarterly reports (20152025)

2015202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pexidartinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.