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Pertuzumab Side Effects

The most commonly reported side effects of pertuzumab include diarrhoea, off label use, and fatigue, based on 30,204 FDA adverse event reports from 2004 to 2025.

Pertuzumab side effects

Percentages show how often each reaction appears relative to total reports for pertuzumab.

1
Diarrhoea13.2%3,981
2
Off Label Use10.3%3,100
3
Fatigue6.5%1,953
4
Nausea6.4%1,937
5
Alopecia5.2%1,568
6
No Adverse Event4.8%1,454
7
Myelosuppression4.7%1,425
8
Disease Progression4.6%1,404
9
Vomiting4.3%1,300
10
Dyspnoea4.0%1,213
11
Death4.0%1,195
12
Pyrexia3.9%1,165
13
Neuropathy Peripheral3.8%1,133
14
Rash3.3%1,004
15
Neutropenia3.3%991

These are voluntary reports and do not establish that pertuzumab caused these reactions.

Report severity

77.2%Serious23,326 reports
31.0%Hospitalizations9,373 reports
9.4%Fatal2,850 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pertuzumab drug interactions

Other drugs that appear in adverse event reports alongside pertuzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Trastuzumab71.7%21,669
2
Docetaxel32.1%9,682
3
Paclitaxel15.4%4,662
4
Carboplatin9.9%2,991
5
Capecitabine6.4%1,938
6
Cyclophosphamide4.2%1,262
7
Letrozole4.1%1,253
8
Epirubicin-hydrochloride3.1%936
9
Denosumab2.7%822
10
Doxorubicin-hydrochloride2.3%698
11
Vinorelbine-tartrate2.3%690
12
Tamoxifen-citrate2.1%646
13
Lapatinib-ditosylate2.1%628
14
Anastrozole1.8%542
15
Fluorouracil1.7%520

Taken alongside

1
Dexamethasone10.0%3,016
2
Trastuzumab8.7%2,623
3
Docetaxel8.1%2,451
4
Acetaminophen6.5%1,955
5
Ondansetron6.0%1,826
6
Carboplatin5.5%1,647
7
Loperamide-hydrochloride4.6%1,387
8
Paclitaxel4.3%1,312
9
Omeprazole3.7%1,131
10
Denosumab3.4%1,016
11
Metoclopramide-hydrochloride3.3%987
12
Pantoprazole-sodium3.2%970
13
Ranitidine3.1%930
14
Sodium-chloride2.9%877
15
Levothyroxine-sodium2.7%817

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pertuzumab side effects

82.6% of pertuzumab adverse event reports involve female patients and 2.7% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female82.6%
Male2.7%
Unknown14.7%

Age group

< 20.1%
2–11<0.1%
12–17<0.1%
18–6473.5%
65+26.4%

What is pertuzumab used for

Conditions and purposes for which patients were taking pertuzumab when the adverse event was reported.

AdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma Of Salivary GlandAdjuvant TherapyAntibiotic TherapyApocrine Breast CarcinomaArthropathyAcute Lymphocytic LeukaemiaAdenocarcinomaAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma Of Salivary GlandAdenocarcinoma Pancreas

Showing 15 of 422 indications

Pertuzumab brand names and reporting trend

Pertuzumab is sold under brand names including Perjeta, Phesgo.

Brand names

Perjeta20,203
Phesgo70

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pertuzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.