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Perindopril Side Effects

The most commonly reported side effects of perindopril include off label use, dyspnoea, and acute kidney injury, based on 35,652 FDA adverse event reports from 2004 to 2025. 5.0% of reports found the drug to be ineffective.

Perindopril side effects

Percentages show how often each reaction appears relative to total reports for perindopril.

1
Off Label Use6.7%2,404
2
Dyspnoea5.9%2,099
3
Acute Kidney Injury5.3%1,899
4
Fatigue5.1%1,831
5
Diarrhoea5.1%1,829
6
Drug Ineffective5.0%1,782
7
Hypertension4.6%1,653
8
Nausea4.3%1,538
9
Headache4.0%1,443
10
Arthralgia4.0%1,413
11
Vomiting3.8%1,363
12
Malaise3.8%1,360
13
Cough3.7%1,331
14
Hypotension3.7%1,303
15
Dizziness3.6%1,297

These are voluntary reports and do not establish that perindopril caused these reactions.

Report severity

98.2%Serious35,004 reports
53.2%Hospitalizations18,969 reports
9.5%Fatal3,403 reports

Seriousness is determined by the reporter, not by OpenClaim.

Perindopril drug interactions

Other drugs that appear in adverse event reports alongside perindopril. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin7.3%2,603
2
Amlodipine6.5%2,312
3
Atorvastatin-calcium5.5%1,959
4
Furosemide5.3%1,890
5
Bisoprolol-fumarate4.7%1,676
6
Rituximab3.9%1,404
7
Aspirin3.9%1,373
8
Spironolactone3.4%1,222
9
Prednisone3.4%1,222
10
Rosuvastatin3.3%1,185
11
Pantoprazole-sodium3.2%1,152
12
Apixaban3.2%1,149
13
Omeprazole3.2%1,140
14
Methotrexate2.9%1,049
15
Indapamide2.9%1,049

Taken alongside

1
Aspirin16.4%5,853
2
Atorvastatin-calcium14.5%5,173
3
Amlodipine12.9%4,616
4
Bisoprolol-fumarate12.5%4,458
5
Acetaminophen12.5%4,448
6
Metformin12.0%4,282
7
Furosemide12.0%4,275
8
Pantoprazole-sodium10.3%3,678
9
Rosuvastatin9.1%3,227
10
Levothyroxine-sodium7.9%2,826
11
Omeprazole7.9%2,805
12
Prednisone7.5%2,672
13
Simvastatin6.3%2,251
14
Metoprolol6.2%2,197
15
Hydrochlorothiazide6.1%2,192

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports perindopril side effects

42.0% of perindopril adverse event reports involve female patients and 48.5% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.0%
Male48.5%
Unknown9.4%

Age group

< 20.4%
2–110.2%
12–170.1%
18–6439.0%
65+60.3%

What is perindopril used for

Conditions and purposes for which patients were taking perindopril when the adverse event was reported.

Accidental Exposure To Product By ChildAcute Coronary SyndromeAcute Myocardial InfarctionAngina PectorisAngina UnstableAngioedemaAngiopathyAngiotensin Converting EnzymeAntacid TherapyAnticoagulant TherapyAntiplatelet TherapyAortic BypassAortic DisorderAortic Valve IncompetenceArrhythmia

Showing 15 of 367 indications

Perindopril brand names and reporting trend

Perindopril is sold under brand names including Aceon, Prestalia.

Brand names

Aceon35,771
Prestalia2,248

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking perindopril with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.