OpenClaim

Pergolide Side Effects

The most commonly reported side effects of pergolide include mitral valve incompetence, aortic valve incompetence, and tricuspid valve incompetence, based on 765 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

Pergolide side effects

Percentages show how often each reaction appears relative to total reports for pergolide.

1
Mitral Valve Incompetence11.9%91
2
Aortic Valve Incompetence9.7%74
3
Tricuspid Valve Incompetence8.0%61
4
Cardiac Valve Disease7.6%58
5
Pathological Gambling6.8%52
6
Dyspnoea6.4%49
7
Condition Aggravated5.2%40
8
Cardiac Failure5.1%39
9
Depression5.0%38
10
Dyskinesia4.8%37
11
Oedema Peripheral4.8%37
12
Pleural Effusion4.7%36
13
Hallucination4.6%35
14
Parkinson's Disease4.3%33
15
Fall4.1%31

These are voluntary reports and do not establish that pergolide caused these reactions.

Report severity

93.6%Serious716 reports
46.3%Hospitalizations354 reports
10.8%Fatal83 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pergolide drug interactions

Other drugs that appear in adverse event reports alongside pergolide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Entacapone15.9%122
2
Levodopa15.3%117
3
Carbidopa11.2%86
4
Ropinirole-hydrochloride10.1%77
5
Pramipexole-dihydrochloride7.7%59
6
Amantadine7.2%55
7
Cabergoline6.3%48
8
Selegiline5.4%41
9
Quetiapine-fumarate2.9%22
10
Clozapine2.7%21
11
Tolcapone2.4%18
12
Apomorphine-hydrochloride2.2%17
13
Trihexyphenidyl-hydrochloride2.1%16
14
Rivastigmine2.1%16
15
Bromocriptine-mesylate2.0%15

Taken alongside

1
Levodopa37.8%289
2
Carbidopa23.9%183
3
Amantadine13.9%106
4
Selegiline11.5%88
5
Entacapone10.8%83
6
Trihexyphenidyl-hydrochloride6.8%52
7
Clonazepam6.1%47
8
Aspirin5.2%40
9
Pramipexole-dihydrochloride5.1%39
10
Ropinirole-hydrochloride4.6%35
11
Furosemide4.3%33
12
Quetiapine-fumarate3.8%29
13
Acetaminophen3.7%28
14
Cabergoline3.4%26
15
Bromocriptine-mesylate3.4%26

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pergolide side effects

40.4% of pergolide adverse event reports involve female patients and 54.0% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.4%
Male54.0%
Unknown5.6%

Age group

< 20.5%
2–110.3%
12–170.2%
18–6442.8%
65+56.2%

What is pergolide used for

Conditions and purposes for which patients were taking pergolide when the adverse event was reported.

AnxietyAtrial FibrillationCerebral DisorderCondition AggravatedCrohn^s DiseaseDecreased Gait VelocityDopaminergic Drug TherapyDrug Use For Unknown IndicationDyskinesiaDystoniaDysarthriaDystoniaFibromyalgiaGait DisturbanceMovement Disorder

Showing 15 of 35 indications

Pergolide brand names and reporting trend

Pergolide is sold under the brand name Pergolide Mesylate.

Brand names

Pergolide Mesylate4

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pergolide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.