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Pentazocine Side Effects

The most commonly reported side effects of pentazocine include pyrexia, dyspnoea, and drug hypersensitivity, based on 6,058 FDA adverse event reports from 2004 to 2025.

Pentazocine side effects

Percentages show how often each reaction appears relative to total reports for pentazocine.

1
Pyrexia7.9%478
2
Dyspnoea7.0%424
3
Drug Hypersensitivity6.9%418
4
Diarrhoea6.6%399
5
Sepsis5.5%332
6
Pruritus5.4%329
7
Nausea5.1%311
8
Vomiting5.0%300
9
Malaise4.7%285
10
Fatigue4.6%281
11
Chills4.4%268
12
Tachycardia4.3%262
13
Abdominal Pain4.1%246
14
Arthralgia4.0%243
15
Dizziness4.0%242

These are voluntary reports and do not establish that pentazocine caused these reactions.

Report severity

91.3%Serious5,528 reports
47.4%Hospitalizations2,874 reports
24.7%Fatal1,499 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pentazocine drug interactions

Other drugs that appear in adverse event reports alongside pentazocine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen9.4%568
2
Omeprazole6.9%421
3
Aspirin5.6%337
4
Docetaxel5.6%337
5
Tramadol-hydrochloride5.2%318
6
Simvastatin4.9%297
7
Hydrochlorothiazide4.8%290
8
Hydromorphone-hydrochloride4.7%287
9
Adalimumab4.6%279
10
Diltiazem4.5%273
11
Pregabalin4.4%269
12
Pravastatin-sodium4.4%267
13
Enoxaparin-sodium4.3%261
14
Celecoxib4.3%260
15
Letrozole4.2%257

Taken alongside

1
Acetaminophen20.2%1,226
2
Furosemide13.3%808
3
Omeprazole10.8%655
4
Aspirin7.3%445
5
Lansoprazole7.3%442
6
Ondansetron7.0%427
7
Meropenem6.9%419
8
Vancomycin6.9%418
9
Metoclopramide-hydrochloride6.9%416
10
Dexamethasone6.7%408
11
Amoxicillin6.6%398
12
Sodium-chloride6.4%387
13
Fluconazole6.3%380
14
Allopurinol6.2%373
15
Hydrocortisone6.1%370

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pentazocine side effects

46.4% of pentazocine adverse event reports involve female patients and 42.4% involve male patients. The largest age group is elderly at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.4%
Male42.4%
Unknown11.2%

Age group

< 21.6%
2–112.5%
12–171.9%
18–6446.7%
65+47.3%

What is pentazocine used for

Conditions and purposes for which patients were taking pentazocine when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SepsisAbscessAbscess NeckAbscess Of Salivary GlandAcneAcquired Immunodeficiency SyndromeAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Pulmonary OedemaAdenomyosis

Showing 15 of 492 indications

Pentazocine brand names and reporting trend

Pentazocine is sold under brand names including Talacen, Talwin.

Brand names

Talacen5,718
Talwin753

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pentazocine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.