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Penpulimab Side Effects

The most commonly reported side effects of penpulimab include myelosuppression, anaemia, and diarrhoea, based on 51 FDA adverse event reports from 2021 to 2025.

Penpulimab side effects

Percentages show how often each reaction appears relative to total reports for penpulimab.

1
Myelosuppression23.5%12
2
Anaemia15.7%8
3
Diarrhoea15.7%8
4
Thrombocytopenia13.7%7
5
Hypothyroidism13.7%7
6
Vomiting13.7%7
7
Rash11.8%6
8
Leukopenia11.8%6
9
Nausea11.8%6
10
Pyrexia9.8%5
11
Hepatic Function Abnormal9.8%5
12
Decreased Appetite9.8%5
13
Fatigue9.8%5
14
Aspartate Aminotransferase Increased9.8%5
15
Alanine Aminotransferase Increased9.8%5

These are voluntary reports and do not establish that penpulimab caused these reactions.

Report severity

100.0%Serious51 reports
43.1%Hospitalizations22 reports
13.7%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Penpulimab drug interactions

Other drugs that appear in adverse event reports alongside penpulimab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel19.6%10
2
Tislelizumab-jsgr19.6%10
3
Toripalimab-tpzi17.6%9
4
Cisplatin17.6%9
5
Pembrolizumab15.7%8
6
Bevacizumab13.7%7
7
Capecitabine9.8%5
8
Carboplatin9.8%5
9
Oxaliplatin9.8%5
10
Atezolizumab9.8%5
11
Lenvatinib-mesylate7.8%4
12
Pemetrexed7.8%4
13
Nivolumab7.8%4
14
Gemcitabine5.9%3
15
Fluorouracil5.9%3

Taken alongside

1
Sodium-chloride13.7%7
2
Gemcitabine7.8%4
3
Dexamethasone7.8%4
4
Cisplatin7.8%4
5
Oxaliplatin5.9%3
6
Fluorouracil5.9%3
7
Denosumab5.9%3
8
Cyclophosphamide3.9%2
9
Doxorubicin-hydrochloride3.9%2
10
Vincristine-sulfate3.9%2
11
Lenalidomide3.9%2
12
Etoposide3.9%2
13
Ifosfamide3.9%2
14
Methylprednisolone3.9%2
15
Dextrose3.9%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports penpulimab side effects

33.3% of penpulimab adverse event reports involve female patients and 47.1% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.3%
Male47.1%
Unknown19.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6465.0%
65+35.0%

What is penpulimab used for

Conditions and purposes for which patients were taking penpulimab when the adverse event was reported.

Adenocarcinoma GastricBile Duct AdenocarcinomaBone Cancer MetastaticBreast CancerCervix Cancer MetastaticCervix CarcinomaCervix Carcinoma RecurrentChoriocarcinomaClear Cell Renal Cell CarcinomaColon Cancer MetastaticColorectal CancerDiffuse Large B-cell LymphomaDrug TherapyDuctal Adenocarcinoma Of PancreasGallbladder Cancer

Showing 15 of 44 indications

Penpulimab brand names and reporting trend

Penpulimab is sold under the brand name Penpulimab-kcqx.

Brand names

Penpulimab-kcqx63

Quarterly reports (20212025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking penpulimab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.