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Penbutolol Side Effects

The most commonly reported side effects of penbutolol include headache, hypoaesthesia, and vomiting, based on 69 FDA adverse event reports from 2004 to 2025. 5.8% of reports found the drug to be ineffective.

Penbutolol side effects

Percentages show how often each reaction appears relative to total reports for penbutolol.

1
Headache7.2%5
2
Drug Ineffective5.8%4
3
Hypoaesthesia4.3%3
4
Vomiting4.3%3
5
Pain4.3%3
6
Drug Hypersensitivity4.3%3
7
Weight Increased4.3%3
8
Nausea4.3%3
9
Injection Site Haemorrhage2.9%2
10
Fall2.9%2
11
Hepatotoxicity2.9%2
12
Renal Failure Acute2.9%2
13
Rhabdomyolysis2.9%2
14
Wrong Technique In Drug Usage Process2.9%2
15
Aspartate Aminotransferase Increased2.9%2

These are voluntary reports and do not establish that penbutolol caused these reactions.

Report severity

50.7%Serious35 reports
30.4%Hospitalizations21 reports
4.3%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Penbutolol drug interactions

Other drugs that appear in adverse event reports alongside penbutolol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Celecoxib4.3%3
2
Simvastatin4.3%3
3
Metoprolol4.3%3
4
Pregabalin4.3%3
5
Tacrolimus4.3%3
6
Adalimumab4.3%3
7
Eszopiclone2.9%2
8
Exenatide-synthetic2.9%2
9
Insulin2.9%2
10
Nitrofurantoin2.9%2
11
Teriparatide2.9%2
12
Sertraline-hydrochloride2.9%2
13
Mycophenolate2.9%2
14
Tamsulosin-hydrochloride2.9%2
15
Aripiprazole2.9%2

Taken alongside

1
Amlodipine14.5%10
2
Furosemide14.5%10
3
Prednisone11.6%8
4
Hydrochlorothiazide10.1%7
5
Gabapentin10.1%7
6
Acetaminophen10.1%7
7
Metoprolol8.7%6
8
Omeprazole8.7%6
9
Fentanyl8.7%6
10
Levothyroxine-sodium8.7%6
11
Metformin8.7%6
12
Aspirin8.7%6
13
Ergocalciferol8.7%6
14
Losartan-potassium7.2%5
15
Calcium7.2%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports penbutolol side effects

72.5% of penbutolol adverse event reports involve female patients and 24.6% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.5%
Male24.6%
Unknown2.9%

Age group

< 20.0%
2–110.0%
12–172.1%
18–6457.4%
65+40.4%

What is penbutolol used for

Conditions and purposes for which patients were taking penbutolol when the adverse event was reported.

Atrial FibrillationBlood Cholesterol AbnormalBlood Cholesterol IncreasedBlood PressureBlood Pressure IncreasedBlood Pressure MeasurementContraceptionHypertensionProduct Used For Unknown IndicationProduct Used For Unknown IndicationRespiratory Tract Infection

Penbutolol brand names and reporting trend

Penbutolol is sold under the brand name Levatol.

Brand names

Levatol6

Quarterly reports (20042025)

20042025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking penbutolol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.