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Pemigatinib Side Effects

The most commonly reported side effects of pemigatinib include off label use, disease progression, and death, based on 752 FDA adverse event reports from 2004 to 2025. 6.0% of reports found the drug to be ineffective.

Pemigatinib side effects

Percentages show how often each reaction appears relative to total reports for pemigatinib.

1
Off Label Use17.3%130
2
Disease Progression16.5%124
3
Death10.4%78
4
Fatigue10.0%75
5
Alopecia7.7%58
6
Cholangiocarcinoma6.8%51
7
Hyperphosphataemia6.6%50
8
Drug Ineffective6.0%45
9
Diarrhoea5.5%41
10
Nausea5.1%38
11
Constipation4.9%37
12
Hospitalisation4.7%35
13
Decreased Appetite4.5%34
14
Stomatitis4.1%31
15
Dry Mouth4.0%30

These are voluntary reports and do not establish that pemigatinib caused these reactions.

Report severity

65.2%Serious490 reports
25.5%Hospitalizations192 reports
18.4%Fatal138 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pemigatinib drug interactions

Other drugs that appear in adverse event reports alongside pemigatinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Gemcitabine4.7%35
2
Oxaliplatin4.3%32
3
Fluorouracil4.1%31
4
Capecitabine3.2%24
5
Cisplatin3.1%23
6
Irinotecan-hydrochloride2.5%19
7
Dexamethasone2.0%15
8
Levoleucovorin1.7%13
9
Levetiracetam1.7%13
10
Carboplatin1.6%12
11
Lacosamide1.5%11
12
Folic-acid1.1%8
13
Futibatinib0.9%7
14
Nivolumab0.8%6
15
Azacitidine0.8%6

Taken alongside

1
Metoprolol2.1%16
2
Omeprazole2.1%16
3
Ergocalciferol1.7%13
4
Levothyroxine-sodium1.6%12
5
Acetaminophen1.5%11
6
Cisplatin1.5%11
7
Gemcitabine1.5%11
8
Metformin1.5%11
9
Gabapentin1.2%9
10
Albuterol1.2%9
11
Losartan-potassium1.2%9
12
Aspirin1.1%8
13
Ondansetron1.1%8
14
Atorvastatin-calcium1.1%8
15
Furosemide1.1%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pemigatinib side effects

20.1% of pemigatinib adverse event reports involve female patients and 15.7% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female20.1%
Male15.7%
Unknown64.2%

Age group

< 22.0%
2–110.0%
12–174.1%
18–6466.9%
65+27.0%

What is pemigatinib used for

Conditions and purposes for which patients were taking pemigatinib when the adverse event was reported.

Acute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcinar Cell Carcinoma Of PancreasAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma Of Salivary GlandAdenocarcinoma PancreasAdenoid Cystic CarcinomaAnal CancerAnal Squamous Cell CarcinomaAstrocytomaB-cell Type Acute Leukaemia

Showing 15 of 101 indications

Pemigatinib brand names and reporting trend

Pemigatinib is sold under the brand name Pemazyre.

Brand names

Pemazyre349

Quarterly reports (20042025)

20202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pemigatinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.