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Pegzilarginase Side Effects

The most commonly reported side effects of pegzilarginase include vomiting, hyperammonaemia, and lethargy, based on 2 FDA adverse event reports from 2016 to 2025.

Pegzilarginase side effects

Percentages show how often each reaction appears relative to total reports for pegzilarginase.

1
Vomiting100.0%2
2
Hyperammonaemia100.0%2
3
Lethargy50.0%1
4
Intensive Care50.0%1
5
Nasopharyngitis50.0%1
6
Nausea50.0%1
7
Somnolence50.0%1
8
Abdominal Discomfort50.0%1
9
Hepatic Enzyme Increased50.0%1
10
Malaise50.0%1

These are voluntary reports and do not establish that pegzilarginase caused these reactions.

Report severity

100.0%Serious2 reports
100.0%Hospitalizations2 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pegzilarginase drug interactions

Other drugs that appear in adverse event reports alongside pegzilarginase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Glycerol-phenylbutyrate50.0%1
2
Sodium-phenylbutyrate50.0%1

Taken alongside

1
Ondansetron50.0%1
2
Levetiracetam50.0%1
3
Baclofen50.0%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pegzilarginase side effects

50.0% of pegzilarginase adverse event reports involve female patients and 50.0% involve male patients. The largest age group is child at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.0%
Male50.0%
Unknown0.0%

Age group

< 20.0%
2–1150.0%
12–170.0%
18–6450.0%
65+0.0%

What is pegzilarginase used for

Conditions and purposes for which patients were taking pegzilarginase when the adverse event was reported.

Arginase Deficiency

Pegzilarginase brand names and reporting trend

Pegzilarginase is sold under the brand name Loargys.

Brand names

Loargys3

Quarterly reports (20162025)

20162025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pegzilarginase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.