OpenClaim

Pegfilgrastim Side Effects

The most commonly reported side effects of pegfilgrastim include device adhesion issue, wrong technique in product usage process, and unintentional medical device removal, based on 99,995 FDA adverse event reports from 2004 to 2025.

Pegfilgrastim side effects

Percentages show how often each reaction appears relative to total reports for pegfilgrastim.

1
Device Adhesion Issue11.4%11,443
2
Wrong Technique In Product Usage Process10.2%10,242
3
Unintentional Medical Device Removal8.9%8,931
4
Device Malfunction7.3%7,322
5
Device Use Error6.0%6,033
6
Device Issue5.1%5,125
7
Accidental Exposure To Product5.0%5,025
8
Off Label Use3.9%3,867
9
Device Occlusion3.3%3,273
10
Febrile Neutropenia3.1%3,096
11
Death2.9%2,911
12
Bone Pain2.6%2,551
13
Fatigue2.4%2,377
14
Neutropenia2.3%2,285
15
Nausea2.2%2,221

These are voluntary reports and do not establish that pegfilgrastim caused these reactions.

Report severity

30.2%Serious30,212 reports
16.4%Hospitalizations16,351 reports
5.7%Fatal5,700 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pegfilgrastim drug interactions

Other drugs that appear in adverse event reports alongside pegfilgrastim. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclophosphamide5.9%5,858
2
Doxorubicin-hydrochloride5.2%5,211
3
Rituximab3.9%3,873
4
Docetaxel3.5%3,473
5
Vincristine-sulfate3.4%3,442
6
Prednisone2.2%2,225
7
Carboplatin2.1%2,109
8
Paclitaxel2.0%2,032
9
Filgrastim1.8%1,825
10
Trastuzumab1.5%1,502
11
Dexamethasone1.5%1,458
12
Bevacizumab1.5%1,457
13
Etoposide1.3%1,309
14
Fluorouracil1.1%1,065
15
Prednisolone1.0%1,040

Taken alongside

1
Dexamethasone5.6%5,551
2
Cyclophosphamide4.8%4,825
3
Ondansetron4.0%3,950
4
Acetaminophen3.6%3,558
5
Doxorubicin-hydrochloride3.3%3,250
6
Docetaxel2.2%2,230
7
Pantoprazole-sodium2.1%2,088
8
Palonosetron-hydrochloride2.1%2,079
9
Carboplatin2.0%1,973
10
Aprepitant2.0%1,965
11
Diphenhydramine1.7%1,736
12
Prednisone1.7%1,663
13
Prochlorperazine1.6%1,639
14
Allopurinol1.6%1,635
15
Lorazepam1.6%1,579

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pegfilgrastim side effects

53.4% of pegfilgrastim adverse event reports involve female patients and 28.1% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.4%
Male28.1%
Unknown18.5%

Age group

< 20.1%
2–110.5%
12–170.4%
18–6455.9%
65+43.1%

What is pegfilgrastim used for

Conditions and purposes for which patients were taking pegfilgrastim when the adverse event was reported.

Abdominal DistensionAbdominal MassAcute Coronary SyndromeAcute Kidney InjuryAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAcute Pulmonary OedemaAdenocarcinomaAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdjuvant Therapy

Showing 15 of 931 indications

Pegfilgrastim brand names and reporting trend

Pegfilgrastim is sold under several brand names including Neulasta, Fulphila, Udenyca.

Brand names

Neulasta15,220
Fulphila10
Udenyca6
Fylnetra2
Ziextenzo1

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pegfilgrastim with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.