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Pegcetacoplan Side Effects

The most commonly reported side effects of pegcetacoplan include fatigue, visual impairment, and haemoglobin decreased, based on 1,549 FDA adverse event reports from 2021 to 2025. 3.6% of reports found the drug to be ineffective.

Pegcetacoplan side effects

Percentages show how often each reaction appears relative to total reports for pegcetacoplan.

1
Fatigue9.4%145
2
Visual Impairment8.5%132
3
Haemoglobin Decreased7.4%114
4
Off Label Use7.2%112
5
Vitreous Floaters7.0%108
6
Haemolysis6.6%103
7
Headache4.9%76
8
Uveitis4.8%74
9
Breakthrough Haemolysis4.5%69
10
Vitritis4.3%67
11
Choroidal Neovascularisation4.1%63
12
Eye Inflammation4.0%62
13
Product Dose Omission Issue3.9%61
14
Neovascular Age-related Macular Degeneration3.7%58
15
Covid-193.7%57

These are voluntary reports and do not establish that pegcetacoplan caused these reactions.

Report severity

65.5%Serious1,015 reports
17.7%Hospitalizations274 reports
5.7%Fatal88 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pegcetacoplan drug interactions

Other drugs that appear in adverse event reports alongside pegcetacoplan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ravulizumab-cwvz2.0%31
2
Eculizumab1.5%23
3
Prednisone1.4%21
4
Penicillin0.9%14
5
Methylprednisolone0.8%13
6
Apixaban0.7%11
7
Mycophenolate0.6%10
8
Deferasirox0.6%9
9
Avacincaptad-pegol-sodium0.6%9
10
Prednisolone0.6%9
11
Ondansetron0.6%9
12
Avatrombopag-maleate0.5%8
13
Pantoprazole-sodium0.5%8
14
Potassium-chloride0.5%8
15
Ursodiol0.5%8

Taken alongside

1
Folic-acid7.6%118
2
Ergocalciferol6.5%100
3
Levothyroxine-sodium4.4%68
4
Aspirin4.0%62
5
Metoprolol3.8%59
6
Cyanocobalamin3.7%58
7
Atorvastatin-calcium3.7%58
8
Amlodipine3.6%56
9
Ravulizumab-cwvz3.5%54
10
Prednisone3.5%54
11
Omeprazole3.4%53
12
Losartan-potassium3.3%51
13
Acetaminophen3.1%48
14
Penicillin3.0%47
15
Aflibercept3.0%46

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pegcetacoplan side effects

17.4% of pegcetacoplan adverse event reports involve female patients and 10.5% involve male patients. The largest age group is elderly at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.4%
Male10.5%
Unknown72.0%

Age group

< 20.3%
2–111.6%
12–172.9%
18–6429.8%
65+65.4%

What is pegcetacoplan used for

Conditions and purposes for which patients were taking pegcetacoplan when the adverse event was reported.

Age-related Macular DegenerationAmyotrophic Lateral SclerosisAnaemiaAplastic AnaemiaAutoimmune Haemolytic AnaemiaBlindnessBlood Lactate DehydrogenaseC3 GlomerulopathyChronic Inflammatory Demyelinating PolyradiculoneuropathyChronic Kidney DiseaseCombined ImmunodeficiencyComplement Factor C3Dry Age-related Macular DegenerationDry Age-related Macular DegenerationGlomerulonephritis

Showing 15 of 45 indications

Pegcetacoplan brand names and reporting trend

Pegcetacoplan is sold under the brand name Syfovre.

Brand names

Syfovre1,299

Quarterly reports (20212025)

2021202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pegcetacoplan with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.