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Pegaspargase Side Effects

The most commonly reported side effects of pegaspargase include febrile neutropenia, pyrexia, and febrile bone marrow aplasia, based on 11,973 FDA adverse event reports from 2004 to 2025.

Pegaspargase side effects

Percentages show how often each reaction appears relative to total reports for pegaspargase.

1
Febrile Neutropenia12.9%1,544
2
Pyrexia6.0%716
3
Febrile Bone Marrow Aplasia5.6%676
4
Vomiting4.6%552
5
Sepsis4.5%542
6
Neutropenia4.4%530
7
Abdominal Pain4.0%480
8
Hypotension3.4%405
9
Thrombocytopenia3.3%390
10
Hypertriglyceridaemia3.2%380
11
Nausea3.1%372
12
Pancreatitis3.1%367
13
Pneumonia3.0%355
14
Hyperbilirubinaemia2.9%345
15
Bacterial Infection2.8%333

These are voluntary reports and do not establish that pegaspargase caused these reactions.

Report severity

97.9%Serious11,721 reports
61.6%Hospitalizations7,371 reports
12.8%Fatal1,538 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pegaspargase drug interactions

Other drugs that appear in adverse event reports alongside pegaspargase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate65.3%7,818
2
Vincristine-sulfate65.2%7,807
3
Cytarabine48.3%5,784
4
Dexamethasone43.9%5,253
5
Cyclophosphamide28.6%3,423
6
Mercaptopurine28.1%3,366
7
Daunorubicin23.2%2,779
8
Hydrocortisone18.8%2,252
9
Doxorubicin-hydrochloride17.4%2,079
10
Prednisone14.5%1,739
11
Etoposide9.0%1,081
12
Thioguanine6.4%762
13
Methylprednisolone6.2%742
14
Prednisolone5.7%688
15
Asparaginase5.4%647

Taken alongside

1
Sulfamethoxazole12.3%1,470
2
Trimethoprim11.2%1,345
3
Ondansetron8.5%1,017
4
Vincristine-sulfate7.6%906
5
Acetaminophen7.3%869
6
Dexamethasone6.0%718
7
Methotrexate6.0%717
8
Cytarabine4.4%531
9
Omeprazole3.3%398
10
Mercaptopurine3.1%366
11
Daunorubicin3.0%361
12
Amphotericin-b3.0%360
13
Vancomycin2.9%342
14
Cyclophosphamide2.7%322
15
Diphenhydramine2.7%322

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pegaspargase side effects

28.2% of pegaspargase adverse event reports involve female patients and 38.2% involve male patients. The largest age group is child at 46%. These figures reflect who reports side effects, not underlying risk.

Sex

Female28.2%
Male38.2%
Unknown33.6%

Age group

< 24.9%
2–1145.8%
12–1722.3%
18–6425.2%
65+1.8%

What is pegaspargase used for

Conditions and purposes for which patients were taking pegaspargase when the adverse event was reported.

Acute Biphenotypic LeukaemiaAcute LeukaemiaAcute Lymphoblastic LeukemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia (in Remission)Acute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia RefractoryAcute Lymphocytic LeukemiaAcute Myeloid LeukaemiaAdministration Site ReactionAngiocentric LymphomaAcute Biphenotypic LeukaemiaAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia (in Remission)

Showing 15 of 189 indications

Pegaspargase brand names and reporting trend

Pegaspargase is sold under the brand name Oncaspar.

Brand names

Oncaspar8,062

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pegaspargase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.