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Pegaptanib Side Effects

The most commonly reported side effects of pegaptanib include visual acuity reduced, retinal haemorrhage, and endophthalmitis, based on 493 FDA adverse event reports from 2005 to 2024. 3.7% of reports found the drug to be ineffective.

Pegaptanib side effects

Percentages show how often each reaction appears relative to total reports for pegaptanib.

1
Visual Acuity Reduced10.8%53
2
Retinal Haemorrhage6.3%31
3
Endophthalmitis5.7%28
4
Intraocular Pressure Increased5.3%26
5
Eye Pain4.5%22
6
Drug Ineffective3.7%18
7
Eye Haemorrhage3.2%16
8
Cerebrovascular Accident3.2%16
9
Off Label Use3.0%15
10
Injection Site Pain2.8%14
11
Vitreous Haemorrhage2.8%14
12
Detachment Of Retinal Pigment Epithelium2.4%12
13
Retinal Detachment2.2%11
14
Cerebral Infarction2.2%11
15
Visual Disturbance2.0%10

These are voluntary reports and do not establish that pegaptanib caused these reactions.

Report severity

92.3%Serious455 reports
29.6%Hospitalizations146 reports
8.3%Fatal41 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pegaptanib drug interactions

Other drugs that appear in adverse event reports alongside pegaptanib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ranibizumab12.8%63
2
Bevacizumab7.1%35
3
Aflibercept3.2%16
4
Verteporfin3.0%15
5
Triamcinolone1.0%5
6
Levofloxacin0.8%4
7
Povidone-iodine0.8%4
8
Ofloxacin0.6%3
9
Metformin0.6%3
10
Atorvastatin-calcium0.4%2
11
Latanoprost0.4%2
12
Irbesartan0.4%2
13
Aspirin0.4%2
14
Moxifloxacin-hydrochloride0.4%2
15
Sodium-bicarbonate0.4%2

Taken alongside

1
Aspirin9.7%48
2
Atorvastatin-calcium5.9%29
3
Amlodipine5.9%29
4
Hydrochlorothiazide5.7%28
5
Levofloxacin5.3%26
6
Lidocaine5.1%25
7
Levothyroxine-sodium4.9%24
8
Povidone-iodine4.7%23
9
Insulin4.7%23
10
Simvastatin4.5%22
11
Gatifloxacin4.1%20
12
Furosemide3.9%19
13
Warfarin3.9%19
14
Tropicamide3.0%15
15
Clopidogrel-bisulfate3.0%15

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pegaptanib side effects

50.9% of pegaptanib adverse event reports involve female patients and 40.2% involve male patients. The largest age group is elderly at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.9%
Male40.2%
Unknown8.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6414.5%
65+85.5%

What is pegaptanib used for

Conditions and purposes for which patients were taking pegaptanib when the adverse event was reported.

Age-related Macular DegenerationAge-related Macular DegenerationCataractChoroidal NeovascularisationDetachment Of Retinal Pigment EpitheliumDiabetic Retinal OedemaDiabetic RetinopathyDrug Use For Unknown IndicationDiabetic Retinal OedemaDiabetic RetinopathyElectromechanical DissociationEye HaemorrhageHistoplasmosisIll-defined DisorderMacular Degeneration

Showing 15 of 31 indications

Pegaptanib brand names and reporting trend

Pegaptanib is sold under the brand name Macugen.

Brand names

Macugen109

Quarterly reports (20052024)

20052010201520202024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pegaptanib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.