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Pazopanib Side Effects

The most commonly reported side effects of pazopanib include death, diarrhoea, and fatigue, based on 26,995 FDA adverse event reports from 2006 to 2025. 5.1% of reports found the drug to be ineffective.

Pazopanib side effects

Percentages show how often each reaction appears relative to total reports for pazopanib.

1
Death16.2%4,370
2
Diarrhoea12.6%3,392
3
Fatigue8.4%2,269
4
Nausea8.3%2,252
5
Malignant Neoplasm Progression6.1%1,642
6
Drug Ineffective5.1%1,386
7
Decreased Appetite5.0%1,349
8
Vomiting4.8%1,304
9
Hypertension4.5%1,215
10
Disease Progression3.5%947
11
Malaise3.3%887
12
Asthenia3.2%876
13
Weight Decreased3.1%836
14
Hair Colour Changes2.9%793
15
Dyspnoea2.9%778

These are voluntary reports and do not establish that pazopanib caused these reactions.

Report severity

66.9%Serious18,064 reports
22.7%Hospitalizations6,129 reports
25.7%Fatal6,940 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pazopanib drug interactions

Other drugs that appear in adverse event reports alongside pazopanib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxorubicin-hydrochloride1.4%391
2
Everolimus1.4%365
3
Gemcitabine1.3%350
4
Nivolumab1.3%338
5
Sunitinib-malate1.1%298
6
Docetaxel0.9%246
7
Ifosfamide0.9%242
8
Paclitaxel0.7%192
9
Cabozantinib0.7%178
10
Topotecan-hydrochloride0.7%177
11
Axitinib0.6%173
12
Sorafenib-tosylate0.5%144
13
Cyclophosphamide0.5%142
14
Vincristine-sulfate0.5%134
15
Bevacizumab0.5%133

Taken alongside

1
Amlodipine4.4%1,195
2
Levothyroxine-sodium4.0%1,069
3
Acetaminophen3.8%1,032
4
Aspirin3.0%815
5
Oxycodone2.9%792
6
Ondansetron2.9%789
7
Metoprolol2.6%710
8
Lisinopril2.3%625
9
Atorvastatin-calcium2.2%601
10
Omeprazole2.2%581
11
Furosemide2.0%536
12
Ergocalciferol2.0%528
13
Gabapentin1.6%434
14
Hydrocodone1.6%430
15
Lorazepam1.6%422

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pazopanib side effects

36.8% of pazopanib adverse event reports involve female patients and 52.2% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.8%
Male52.2%
Unknown10.9%

Age group

< 2<0.1%
2–110.6%
12–171.4%
18–6451.3%
65+46.7%

What is pazopanib used for

Conditions and purposes for which patients were taking pazopanib when the adverse event was reported.

Abdominal DistensionAbdominal MassAbdominal PainAbnormal Loss Of WeightAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenoid Cystic CarcinomaAdrenal CarcinomaAdrenal Gland CancerAdrenal Gland Cancer MetastaticAdverse Drug ReactionAesthesioneuroblastomaAgranulocytosis

Showing 15 of 846 indications

Pazopanib brand names and reporting trend

Pazopanib is sold under the brand name Votrient.

Brand names

Votrient4

Quarterly reports (20062025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pazopanib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.