OpenClaim

Patisiran Side Effects

The most commonly reported side effects of patisiran include death, product dose omission issue, and fatigue, based on 2,777 FDA adverse event reports from 2018 to 2025.

Patisiran side effects

Percentages show how often each reaction appears relative to total reports for patisiran.

1
Death9.5%264
2
Product Dose Omission Issue6.3%176
3
Fatigue6.2%172
4
Hospitalisation4.7%131
5
Infusion Related Reaction4.6%128
6
Fall4.1%114
7
Asthenia4.0%112
8
Intentional Dose Omission3.9%108
9
Cardiac Failure3.5%96
10
Dyspnoea3.3%91
11
Malaise3.1%86
12
Nausea3.0%83
13
Inappropriate Schedule Of Product Administration2.9%81
14
Diarrhoea2.9%80
15
Dizziness2.8%77

These are voluntary reports and do not establish that patisiran caused these reactions.

Report severity

67.4%Serious1,873 reports
38.2%Hospitalizations1,061 reports
14.7%Fatal408 reports

Seriousness is determined by the reporter, not by OpenClaim.

Patisiran drug interactions

Other drugs that appear in adverse event reports alongside patisiran. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Diphenhydramine2.8%78
2
Dexamethasone2.0%55
3
Tafamidis1.2%33
4
Acetaminophen1.0%27
5
Inotersen-sodium0.9%25
6
Dexchlorpheniramine-maleate0.7%19
7
Gabapentin0.6%18
8
Famotidine0.5%14
9
Vutrisiran-sodium0.4%12
10
Cetirizine-hydrochloride0.4%10
11
Insulin0.3%8
12
Escitalopram-oxalate0.3%8
13
Pimozide0.3%7
14
Tramadol-hydrochloride0.2%6
15
Atorvastatin-calcium0.2%6

Taken alongside

1
Acetaminophen15.1%418
2
Dexamethasone14.4%400
3
Famotidine12.8%356
4
Diphenhydramine9.5%265
5
Vitamin-a7.7%214
6
Furosemide5.9%163
7
Tafamidis4.4%121
8
Pregabalin4.3%120
9
Pantoprazole-sodium3.8%105
10
Gabapentin3.6%101
11
Spironolactone3.4%95
12
Atorvastatin-calcium3.2%90
13
Ergocalciferol3.2%89
14
Aspirin3.2%88
15
Apixaban3.1%85

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports patisiran side effects

8.6% of patisiran adverse event reports involve female patients and 16.3% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female8.6%
Male16.3%
Unknown75.1%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6437.4%
65+62.6%

What is patisiran used for

Conditions and purposes for which patients were taking patisiran when the adverse event was reported.

AmyloidosisAmyloidosis SenileAcquired Attr AmyloidosisAdenomatous Polyposis ColiAmyloidosisAmyloidosis SenileAutonomic Nervous System ImbalanceCardiac AmyloidosisCardiac FailureCardiac AmyloidosisCardiomyopathyDisease SusceptibilityFamilial AmyloidosisFamilial AmyloidosisFoetal Exposure During Pregnancy

Showing 15 of 31 indications

Patisiran brand names and reporting trend

Patisiran is sold under the brand name Onpattro.

Brand names

Onpattro91

Quarterly reports (20182025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking patisiran with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.