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Pasireotide Side Effects

The most commonly reported side effects of pasireotide include blood glucose increased, hyperglycaemia, and diabetes mellitus, based on 2,218 FDA adverse event reports from 2011 to 2025. 7.2% of reports found the drug to be ineffective.

Pasireotide side effects

Percentages show how often each reaction appears relative to total reports for pasireotide.

1
Blood Glucose Increased11.8%262
2
Hyperglycaemia11.2%248
3
Diabetes Mellitus11.0%245
4
Nausea10.5%232
5
Diarrhoea9.4%208
6
Fatigue9.3%206
7
Headache8.0%178
8
Off Label Use7.3%161
9
Drug Ineffective7.2%160
10
Dizziness6.0%132
11
Vomiting5.8%128
12
Weight Decreased4.4%98
13
Asthenia4.4%98
14
Blood Pressure Increased4.4%98
15
Abdominal Pain4.0%88

These are voluntary reports and do not establish that pasireotide caused these reactions.

Report severity

70.6%Serious1,566 reports
28.4%Hospitalizations629 reports
6.8%Fatal150 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pasireotide drug interactions

Other drugs that appear in adverse event reports alongside pasireotide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Octreotide-acetate5.1%113
2
Cabergoline4.0%88
3
Temozolomide3.7%81
4
Metformin3.6%80
5
Pegvisomant2.3%50
6
Everolimus2.2%48
7
Osilodrostat-phosphate1.7%38
8
Ketoconazole1.5%34
9
Hydrocortisone1.4%30
10
Metyrapone1.3%29
11
Capecitabine1.2%27
12
Valsartan1.1%24
13
Rosuvastatin1.1%24
14
Bevacizumab1.0%23
15
Amlodipine0.9%21

Taken alongside

1
Levothyroxine-sodium11.3%251
2
Metformin10.4%230
3
Cabergoline8.5%188
4
Insulin7.6%169
5
Ergocalciferol5.6%124
6
Hydrocortisone5.0%111
7
Atorvastatin-calcium5.0%110
8
Amlodipine4.7%105
9
Hydrochlorothiazide4.2%93
10
Pegvisomant3.6%80
11
Aspirin3.5%78
12
Spironolactone3.4%75
13
Sitagliptin3.3%73
14
Pantoprazole-sodium3.2%72
15
Acetaminophen3.0%66

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pasireotide side effects

49.5% of pasireotide adverse event reports involve female patients and 24.6% involve male patients. The largest age group is adult at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.5%
Male24.6%
Unknown25.8%

Age group

< 20.2%
2–11<0.1%
12–171.0%
18–6478.3%
65+20.5%

What is pasireotide used for

Conditions and purposes for which patients were taking pasireotide when the adverse event was reported.

Acral OvergrowthAcromegalyActh-producing Pituitary TumourActh-producing Pituitary TumourAdenoma BenignAdrenal InsufficiencyAcromegalyAdrenocortical CarcinomaAlbright^s DiseaseBile Duct CancerBlood CorticotrophinBenign NeoplasmBlood Corticotrophin IncreasedBone DisorderCarcinoid Syndrome

Showing 15 of 120 indications

Pasireotide brand names and reporting trend

Pasireotide is sold under brand names including Signifor, Signifor Lar Kit.

Brand names

Signifor701
Signifor Lar Kit32

Quarterly reports (20112025)

20112016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pasireotide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.