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Paroxetine Side Effects

The most commonly reported side effects of paroxetine include drug withdrawal syndrome, fatigue, and drug exposure during pregnancy, based on 98,158 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Paroxetine side effects

Percentages show how often each reaction appears relative to total reports for paroxetine.

1
Drug Withdrawal Syndrome4.6%4,544
2
Drug Ineffective3.9%3,803
3
Fatigue3.7%3,676
4
Drug Exposure During Pregnancy3.4%3,379
5
Nausea3.4%3,351
6
Nausea3.2%3,095
7
Dizziness3.2%3,092
8
Drug Ineffective3.0%2,961
9
Anxiety3.0%2,957
10
Anxiety2.9%2,826
11
Headache2.8%2,788
12
Diarrhoea2.8%2,754
13
Dizziness2.6%2,537
14
Depression2.5%2,474
15
Off Label Use2.5%2,424

These are voluntary reports and do not establish that paroxetine caused these reactions.

Report severity

71.1%Serious69,822 reports
32.1%Hospitalizations31,540 reports
9.3%Fatal9,163 reports

Seriousness is determined by the reporter, not by OpenClaim.

Paroxetine drug interactions

Other drugs that appear in adverse event reports alongside paroxetine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate4.4%4,326
2
Adalimumab2.4%2,354
3
Alprazolam2.4%2,344
4
Olanzapine2.3%2,209
5
Acetaminophen2.0%1,922
6
Bupropion1.9%1,861
7
Sertraline-hydrochloride1.6%1,618
8
Omeprazole1.6%1,593
9
Aripiprazole1.6%1,592
10
Risperidone1.6%1,590
11
Diazepam1.6%1,556
12
Lamotrigine1.6%1,539
13
Lorazepam1.5%1,455
14
Pregabalin1.4%1,388
15
Lenalidomide1.4%1,330

Taken alongside

1
Acetaminophen9.6%9,397
2
Aspirin8.3%8,195
3
Levothyroxine-sodium8.3%8,123
4
Omeprazole7.1%6,957
5
Alprazolam6.3%6,176
6
Atorvastatin-calcium6.3%6,148
7
Ergocalciferol6.2%6,126
8
Gabapentin5.9%5,828
9
Furosemide5.5%5,445
10
Albuterol5.4%5,277
11
Metformin5.2%5,140
12
Lisinopril5.1%5,045
13
Amlodipine5.1%5,009
14
Metoprolol4.8%4,740
15
Clonazepam4.8%4,721

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports paroxetine side effects

60.9% of paroxetine adverse event reports involve female patients and 31.6% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.9%
Male31.6%
Unknown7.5%

Age group

< 22.0%
2–110.5%
12–171.6%
18–6464.9%
65+31.0%

What is paroxetine used for

Conditions and purposes for which patients were taking paroxetine when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAbnormal BehaviourAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAcneAcrophobiaActivities Of Daily Living ImpairedAcute PsychosisAdjustment DisorderAdjustment Disorder With AnxietyAdjustment Disorder With Depressed MoodAdjustment Disorder With Mixed Anxiety And Depressed Mood

Showing 15 of 817 indications

Paroxetine brand names and reporting trend

Paroxetine is sold under the brand name Paroxetine.

Brand names

Paroxetine552

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking paroxetine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.