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Paromomycin Side Effects

The most commonly reported side effects of paromomycin include diarrhoea, off label use, and vomiting, based on 214 FDA adverse event reports from 2004 to 2025. 10.7% of reports found the drug to be ineffective.

Paromomycin side effects

Percentages show how often each reaction appears relative to total reports for paromomycin.

1
Diarrhoea14.5%31
2
Drug Ineffective10.7%23
3
Off Label Use9.8%21
4
Vomiting7.5%16
5
Pyrexia6.1%13
6
Anaemia6.1%13
7
Oedema6.1%13
8
General Physical Health Deterioration5.6%12
9
Weight Decreased5.6%12
10
Hypoalbuminaemia4.7%10
11
Multiple Organ Dysfunction Syndrome4.7%10
12
Drug-induced Liver Injury4.7%10
13
Nausea4.2%9
14
Pathogen Resistance3.7%8
15
Tinnitus3.7%8

These are voluntary reports and do not establish that paromomycin caused these reactions.

Report severity

86.4%Serious185 reports
41.6%Hospitalizations89 reports
22.4%Fatal48 reports

Seriousness is determined by the reporter, not by OpenClaim.

Paromomycin drug interactions

Other drugs that appear in adverse event reports alongside paromomycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metronidazole14.5%31
2
Lamivudine8.9%19
3
Azithromycin7.9%17
4
Fludarabine-phosphate7.5%16
5
Mycophenolate7.0%15
6
Tacrolimus7.0%15
7
Nitazoxanide6.5%14
8
Ritonavir5.1%11
9
Methylprednisolone5.1%11
10
Cyclophosphamide5.1%11
11
Metoclopramide-hydrochloride5.1%11
12
Zidovudine4.7%10
13
Insulin4.7%10
14
Furosemide4.2%9
15
Amphotericin-b3.7%8

Taken alongside

1
Ganciclovir13.1%28
2
Azithromycin10.3%22
3
Pantoprazole-sodium9.8%21
4
Amphotericin-b9.3%20
5
Meropenem8.9%19
6
Furosemide7.5%16
7
Acyclovir7.0%15
8
Acetaminophen6.5%14
9
Nitazoxanide6.5%14
10
Amoxicillin6.5%14
11
Methylprednisolone6.1%13
12
Metronidazole6.1%13
13
Propranolol-hydrochloride4.7%10
14
Spironolactone4.7%10
15
Lactulose4.7%10

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports paromomycin side effects

39.7% of paromomycin adverse event reports involve female patients and 50.9% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.7%
Male50.9%
Unknown9.3%

Age group

< 26.2%
2–1110.2%
12–175.1%
18–6458.2%
65+20.3%

What is paromomycin used for

Conditions and purposes for which patients were taking paromomycin when the adverse event was reported.

AmoebiasisAmoebic DysenteryAntibiotic ProphylaxisAmoebiasisAmoebic ColitisAmoebic DysenteryAmoebomaBiliary Catheter InsertionBlastocystis InfectionBlastocystis InfectionCryptosporidiosis InfectionCutaneous LeishmaniasisCryptosporidiosis InfectionDiarrhoeaDientamoeba Infection

Showing 15 of 49 indications

Paromomycin brand names and reporting trend

Paromomycin is sold under the brand name Humatin.

Brand names

Humatin153

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking paromomycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.