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Paramethadione Side Effects

The most commonly reported side effects of paramethadione include retroperitoneal haemorrhage, aspiration, and cardiac arrest, based on 5 FDA adverse event reports from 2004 to 2025.

Paramethadione side effects

Percentages show how often each reaction appears relative to total reports for paramethadione.

1
Retroperitoneal Haemorrhage20.0%1
2
Aspiration20.0%1
3
Cardiac Arrest20.0%1
4
Dizziness20.0%1
5
Sudden Death20.0%1
6
Syncope20.0%1
7
Menorrhagia20.0%1
8
Product Prescribing Issue20.0%1
9
Headache20.0%1
10
Uterine Leiomyoma20.0%1
11
Product Use In Unapproved Indication20.0%1
12
Off Label Use20.0%1
13
Adnexa Uteri Pain20.0%1
14
Back Pain20.0%1
15
Limb Discomfort20.0%1

These are voluntary reports and do not establish that paramethadione caused these reactions.

Report severity

100.0%Serious5 reports
20.0%Hospitalizations1 reports
20.0%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Paramethadione drug interactions

Other drugs that appear in adverse event reports alongside paramethadione. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Heparin20.0%1
2
Carbamazepine20.0%1
3
Drospirenone20.0%1
4
Ethinyl-estradiol20.0%1
5
Clonazepam20.0%1
6
Pimavanserin20.0%1

Taken alongside

1
Phenytoin40.0%2
2
Fluticasone20.0%1
3
Salmeterol-xinafoate20.0%1
4
Clonazepam20.0%1
5
Prednisone20.0%1
6
Aspirin20.0%1
7
Escitalopram-oxalate20.0%1
8
Ibuprofen20.0%1
9
Gabapentin20.0%1
10
Atenolol20.0%1
11
Furosemide20.0%1
12
Valproate-sodium20.0%1
13
Primidone20.0%1
14
Carbamazepine20.0%1
15
Ethosuximide20.0%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports paramethadione side effects

80.0% of paramethadione adverse event reports involve female patients and 0.0% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female80.0%
Male0.0%
Unknown20.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6450.0%
65+50.0%

Paramethadione brand names and reporting trend

Paramethadione is sold under the brand name Paradione.

Brand names

Paradione5

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking paramethadione with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.