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Pantoprazole Side Effects

The most commonly reported side effects of pantoprazole include chronic kidney disease, fatigue, and acute kidney injury, based on 337,160 FDA adverse event reports from 2004 to 2025. 5.6% of reports found the drug to be ineffective.

Pantoprazole side effects

Percentages show how often each reaction appears relative to total reports for pantoprazole.

1
Chronic Kidney Disease8.7%29,345
2
Fatigue7.0%23,446
3
Acute Kidney Injury6.4%21,477
4
Nausea6.1%20,533
5
Off Label Use5.9%19,865
6
Diarrhoea5.9%19,727
7
Dyspnoea5.8%19,495
8
Drug Ineffective5.6%18,829
9
Pain5.3%17,994
10
Headache4.5%15,089
11
Vomiting4.2%14,209
12
Renal Failure4.1%13,942
13
Arthralgia4.0%13,520
14
Asthenia3.7%12,633
15
Pyrexia3.7%12,481

These are voluntary reports and do not establish that pantoprazole caused these reactions.

Report severity

81.9%Serious276,058 reports
43.3%Hospitalizations146,054 reports
11.1%Fatal37,424 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pantoprazole drug interactions

Other drugs that appear in adverse event reports alongside pantoprazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole9.9%33,434
2
Esomeprazole9.4%31,637
3
Lansoprazole8.7%29,274
4
Dexlansoprazole5.5%18,606
5
Adalimumab5.4%18,086
6
Lenalidomide4.2%14,163
7
Rituximab4.2%14,094
8
Methotrexate4.0%13,595
9
Prednisone3.9%13,239
10
Infliximab3.4%11,353
11
Acetaminophen3.4%11,345
12
Etanercept3.3%11,147
13
Tocilizumab2.9%9,917
14
Abatacept2.9%9,697
15
Naproxen2.6%8,621

Taken alongside

1
Acetaminophen18.9%63,606
2
Aspirin17.1%57,546
3
Furosemide13.6%45,955
4
Atorvastatin-calcium13.4%45,084
5
Ergocalciferol13.2%44,364
6
Levothyroxine-sodium13.1%44,066
7
Metoprolol11.9%40,215
8
Amlodipine11.1%37,391
9
Prednisone10.7%36,130
10
Albuterol10.0%33,852
11
Gabapentin9.4%31,732
12
Ondansetron8.7%29,249
13
Metformin8.2%27,514
14
Lisinopril8.1%27,296
15
Insulin7.3%24,755

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pantoprazole side effects

52.6% of pantoprazole adverse event reports involve female patients and 36.6% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.6%
Male36.6%
Unknown10.9%

Age group

< 20.3%
2–110.4%
12–170.5%
18–6449.0%
65+49.8%

What is pantoprazole used for

Conditions and purposes for which patients were taking pantoprazole when the adverse event was reported.

Abdominal AbscessAbdominal DiscomfortAbdominal DistensionAbdominal HerniaAbdominal InfectionAbdominal OperationAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal RigidityAbdominal SymptomAbdominal TendernessAbnormal BehaviourAbnormal FaecesAbscess

Showing 15 of 1,598 indications

Pantoprazole brand names and reporting trend

Pantoprazole is sold under the brand name Pantoprazole Sodium In 0.9% Sodium Chloride.

Brand names

Pantoprazole Sodium In 0.9% Sodium Chloride294,235

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pantoprazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.