OpenClaim

Panobinostat Side Effects

The most commonly reported side effects of panobinostat include diarrhoea, plasma cell myeloma, and death, based on 2,004 FDA adverse event reports from 2004 to 2025. 6.1% of reports found the drug to be ineffective.

Panobinostat side effects

Percentages show how often each reaction appears relative to total reports for panobinostat.

1
Diarrhoea19.0%381
2
Plasma Cell Myeloma16.7%334
3
Death11.8%236
4
Platelet Count Decreased9.9%199
5
Fatigue9.0%181
6
Nausea8.6%172
7
Malignant Neoplasm Progression8.2%165
8
Thrombocytopenia7.2%145
9
Drug Ineffective6.1%122
10
Off Label Use6.0%120
11
Vomiting5.7%114
12
Anaemia5.3%107
13
Pyrexia5.1%102
14
Pneumonia5.0%100
15
White Blood Cell Count Decreased4.2%85

These are voluntary reports and do not establish that panobinostat caused these reactions.

Report severity

81.2%Serious1,628 reports
31.4%Hospitalizations629 reports
29.5%Fatal591 reports

Seriousness is determined by the reporter, not by OpenClaim.

Panobinostat drug interactions

Other drugs that appear in adverse event reports alongside panobinostat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bortezomib35.5%712
2
Dexamethasone30.6%614
3
Lenalidomide11.1%222
4
Pomalidomide9.4%189
5
Carfilzomib7.8%156
6
Daratumumab5.1%103
7
Cyclophosphamide4.8%96
8
Thalidomide4.4%89
9
Ixazomib-citrate3.5%70
10
Melphalan3.2%65
11
Doxorubicin-hydrochloride2.0%40
12
Etoposide1.6%32
13
Venetoclax1.1%23
14
Prednisone1.1%22
15
Trametinib1.1%22

Taken alongside

1
Dexamethasone16.8%337
2
Bortezomib10.4%208
3
Acyclovir9.9%198
4
Aspirin7.4%149
5
Acetaminophen4.9%98
6
Oxycodone4.7%94
7
Amlodipine4.7%94
8
Omeprazole4.2%85
9
Ergocalciferol3.9%78
10
Ondansetron3.9%78
11
Gabapentin3.7%74
12
Zoledronic-acid3.7%74
13
Calcium3.5%70
14
Pantoprazole-sodium3.4%69
15
Furosemide3.3%66

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports panobinostat side effects

34.7% of panobinostat adverse event reports involve female patients and 39.6% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.7%
Male39.6%
Unknown25.7%

Age group

< 20.0%
2–112.7%
12–171.3%
18–6441.9%
65+54.0%

What is panobinostat used for

Conditions and purposes for which patients were taking panobinostat when the adverse event was reported.

Acute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdrenal Gland CancerAllogenic Stem Cell TransplantationAnaplastic AstrocytomaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAngiocentric LymphomaAtypical Teratoid/rhabdoid Tumour Of CnsAcute Myeloid LeukaemiaB-cell LymphomaBladder CancerBone CancerBone Marrow Conditioning RegimenBrain Neoplasm Malignant

Showing 15 of 110 indications

Panobinostat brand names and reporting trend

Panobinostat is sold under the brand name Farydak.

Brand names

Farydak1,011

Quarterly reports (20042025)

2010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking panobinostat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.