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Pamidronate Side Effects

The most commonly reported side effects of pamidronate include osteonecrosis, osteonecrosis of jaw, and bone disorder, based on 10,473 FDA adverse event reports from 2004 to 2025.

Pamidronate side effects

Percentages show how often each reaction appears relative to total reports for pamidronate.

1
Osteonecrosis16.3%1,702
2
Osteonecrosis Of Jaw7.5%784
3
Bone Disorder7.1%747
4
Tooth Extraction7.0%729
5
Pain6.3%659
6
Osteonecrosis Of Jaw6.1%636
7
Pain5.7%596
8
Fatigue5.4%567
9
Diarrhoea4.6%483
10
Dyspnoea4.4%464
11
Osteomyelitis4.3%453
12
Nausea4.2%438
13
Pneumonia4.1%429
14
Anxiety4.1%426
15
Back Pain3.8%401

These are voluntary reports and do not establish that pamidronate caused these reactions.

Report severity

93.9%Serious9,833 reports
35.7%Hospitalizations3,741 reports
15.5%Fatal1,628 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pamidronate drug interactions

Other drugs that appear in adverse event reports alongside pamidronate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Zoledronic-acid24.1%2,523
2
Lenalidomide16.8%1,759
3
Dexamethasone10.6%1,110
4
Bortezomib5.4%570
5
Thalidomide4.0%414
6
Pomalidomide3.6%373
7
Capecitabine2.3%246
8
Trastuzumab2.1%218
9
Prednisone2.0%210
10
Cyclophosphamide2.0%210
11
Melphalan1.7%176
12
Letrozole1.6%170
13
Carfilzomib1.6%169
14
Bevacizumab1.6%164
15
Alendronate-sodium1.6%163

Taken alongside

1
Dexamethasone18.0%1,881
2
Acetaminophen14.5%1,522
3
Aspirin11.8%1,241
4
Acyclovir9.0%940
5
Omeprazole8.1%852
6
Oxycodone8.0%835
7
Furosemide7.8%821
8
Ergocalciferol7.4%774
9
Prednisone6.4%673
10
Gabapentin6.3%661
11
Pantoprazole-sodium6.3%661
12
Calcium6.2%647
13
Levothyroxine-sodium6.1%642
14
Ondansetron5.7%600
15
Warfarin5.5%575

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pamidronate side effects

56.5% of pamidronate adverse event reports involve female patients and 37.5% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.5%
Male37.5%
Unknown6.1%

Age group

< 21.1%
2–112.6%
12–171.3%
18–6444.0%
65+50.9%

What is pamidronate used for

Conditions and purposes for which patients were taking pamidronate when the adverse event was reported.

Accident At WorkAcute Kidney InjuryAcute Lymphocytic LeukaemiaAdenocarcinomaAdjuvant TherapyAdult T-cell Lymphoma/leukaemiaAdverse EventAlbright^s DiseaseAmyloidosisAnalgesic TherapyAnkylosing SpondylitisAntioestrogen TherapyAnxietyArteriosclerosisArthralgia

Showing 15 of 356 indications

Pamidronate brand names and reporting trend

Pamidronate is sold under the brand name Aredia.

Brand names

Aredia6,058

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pamidronate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.