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Palopegteriparatide Side Effects

The most commonly reported side effects of palopegteriparatide include hypercalcaemia, hypocalcaemia, and nausea, based on 109 FDA adverse event reports from 2024 to 2025.

Palopegteriparatide side effects

Percentages show how often each reaction appears relative to total reports for palopegteriparatide.

1
Hypercalcaemia11.9%13
2
Hypocalcaemia11.0%12
3
Nausea8.3%9
4
Headache8.3%9
5
Blood Calcium Decreased7.3%8
6
Paraesthesia6.4%7
7
Fatigue6.4%7
8
Arthralgia6.4%7
9
Injection Site Reaction6.4%7
10
Product Dose Omission Issue6.4%7
11
Pruritus5.5%6
12
Muscle Spasms4.6%5
13
Dizziness4.6%5
14
Blood Calcium Increased4.6%5
15
Hypoaesthesia4.6%5

These are voluntary reports and do not establish that palopegteriparatide caused these reactions.

Report severity

51.4%Serious56 reports
33.0%Hospitalizations36 reports
0.9%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Palopegteriparatide drug interactions

Other drugs that appear in adverse event reports alongside palopegteriparatide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Parathyroid-hormone3.7%4
2
Levothyroxine-sodium1.8%2
3
Tirzepatide0.9%1
4
Perampanel0.9%1
5
Galcanezumab-gnlm0.9%1
6
Doxycycline0.9%1
7
Oxcarbazepine0.9%1
8
Burosumab-twza0.9%1
9
Oxycodone0.9%1
10
Methylprednisolone0.9%1
11
Dupilumab0.9%1

Taken alongside

1
Calcium22.9%25
2
Levothyroxine-sodium19.3%21
3
Calcitriol19.3%21
4
Cholecalciferol7.3%8
5
Magnesium-acetate-tetrahydrate4.6%5
6
Ergocalciferol4.6%5
7
Hydrochlorothiazide4.6%5
8
Cyanocobalamin4.6%5
9
Albuterol3.7%4
10
Calcium-carbonate3.7%4
11
Gabapentin3.7%4
12
Levetiracetam2.8%3
13
Alprazolam2.8%3
14
Atorvastatin-calcium2.8%3
15
Ascorbic-acid2.8%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports palopegteriparatide side effects

9.2% of palopegteriparatide adverse event reports involve female patients and 0.0% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female9.2%
Male0.0%
Unknown90.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6470.0%
65+30.0%

What is palopegteriparatide used for

Conditions and purposes for which patients were taking palopegteriparatide when the adverse event was reported.

Blood Calcium AbnormalHypoparathyroidismParathyroid DisorderPost Procedural HypoparathyroidismPost Procedural HypothyroidismProduct Used For Unknown Indication

Palopegteriparatide brand names and reporting trend

Palopegteriparatide is sold under the brand name Yorvipath.

Brand names

Yorvipath35

Quarterly reports (20242025)

20242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking palopegteriparatide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.