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Palonosetron Side Effects

The most commonly reported side effects of palonosetron include nausea, death, and off label use, based on 13,845 FDA adverse event reports from 2004 to 2025.

Palonosetron side effects

Percentages show how often each reaction appears relative to total reports for palonosetron.

1
Nausea10.7%1,476
2
Death8.8%1,223
3
Off Label Use7.8%1,080
4
Alopecia7.3%1,017
5
Fatigue7.2%998
6
Diarrhoea7.1%986
7
Vomiting6.4%880
8
Pyrexia5.3%737
9
Decreased Appetite5.2%722
10
Dyspnoea4.9%679
11
Febrile Neutropenia4.9%677
12
Neutropenia4.9%674
13
Anaemia4.5%628
14
Constipation4.2%585
15
Asthenia3.7%509

These are voluntary reports and do not establish that palonosetron caused these reactions.

Report severity

89.9%Serious12,443 reports
45.4%Hospitalizations6,284 reports
21.0%Fatal2,905 reports

Seriousness is determined by the reporter, not by OpenClaim.

Palonosetron drug interactions

Other drugs that appear in adverse event reports alongside palonosetron. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab14.6%2,018
2
Carboplatin13.3%1,846
3
Paclitaxel11.0%1,518
4
Docetaxel10.4%1,442
5
Oxaliplatin8.8%1,225
6
Cyclophosphamide7.7%1,060
7
Fluorouracil7.6%1,054
8
Doxorubicin-hydrochloride6.0%837
9
Irinotecan-hydrochloride5.9%817
10
Aprepitant5.7%786
11
Trastuzumab5.5%764
12
Dexamethasone5.5%758
13
Fosaprepitant-dimeglumine5.2%722
14
Cisplatin4.7%648
15
Rituximab4.5%629

Taken alongside

1
Dexamethasone61.8%8,552
2
Aprepitant22.0%3,040
3
Acetaminophen19.0%2,628
4
Diphenhydramine18.6%2,582
5
Ondansetron13.6%1,884
6
Pegfilgrastim12.5%1,728
7
Fosaprepitant-dimeglumine11.9%1,644
8
Famotidine9.6%1,330
9
Lorazepam9.5%1,311
10
Furosemide9.4%1,295
11
Netupitant9.0%1,249
12
Carboplatin8.5%1,183
13
Ranitidine8.5%1,173
14
Cyclophosphamide8.4%1,158
15
Prochlorperazine7.9%1,095

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports palonosetron side effects

55.2% of palonosetron adverse event reports involve female patients and 39.6% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.2%
Male39.6%
Unknown5.2%

Age group

< 20.2%
2–111.1%
12–171.0%
18–6456.9%
65+40.9%

What is palonosetron used for

Conditions and purposes for which patients were taking palonosetron when the adverse event was reported.

Abdominal DistensionAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdenocarcinoma PancreasAdjuvant TherapyAdverse Drug ReactionAdverse EventAdverse ReactionAllergy ProphylaxisAnaesthesiaAnal CancerAngioimmunoblastic T-cell LymphomaAntiallergic TherapyAntibiotic ProphylaxisAntiemetic Supportive Care

Showing 15 of 265 indications

Palonosetron brand names and reporting trend

Palonosetron is sold under the brand name Aloxi.

Brand names

Aloxi134

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking palonosetron with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.