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Pacritinib Side Effects

The most commonly reported side effects of pacritinib include diarrhoea, off label use, and fatigue, based on 2,763 FDA adverse event reports from 2016 to 2025. 3.9% of reports found the drug to be ineffective.

Pacritinib side effects

Percentages show how often each reaction appears relative to total reports for pacritinib.

1
Diarrhoea20.9%578
2
Off Label Use19.3%533
3
Fatigue12.6%348
4
Product Dose Omission Issue10.9%301
5
Death10.0%276
6
Nausea9.6%266
7
Platelet Count Decreased9.4%261
8
Haemoglobin Decreased7.1%195
9
Asthenia5.0%138
10
Drug Ineffective3.9%109
11
Dizziness3.7%103
12
Splenomegaly3.5%97
13
Transfusion3.0%84
14
Dyspnoea3.0%82
15
Constipation2.9%80

These are voluntary reports and do not establish that pacritinib caused these reactions.

Report severity

35.9%Serious991 reports
17.9%Hospitalizations495 reports
11.3%Fatal312 reports

Seriousness is determined by the reporter, not by OpenClaim.

Pacritinib drug interactions

Other drugs that appear in adverse event reports alongside pacritinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ruxolitinib3.3%91
2
Fedratinib-hydrochloride0.2%6
3
Posaconazole0.2%6
4
Tacrolimus0.2%5
5
Lenalidomide0.2%5
6
Venetoclax0.2%5
7
Aspirin0.1%4
8
Sirolimus0.1%4
9
Hydroxyurea0.1%4
10
Deferasirox0.1%3
11
Decitabine0.1%3
12
Deferoxamine-mesylate<0.1%2
13
Prednisone<0.1%2
14
Celecoxib<0.1%2
15
Losartan-potassium<0.1%2

Taken alongside

1
Ergocalciferol13.0%358
2
Acetaminophen11.9%330
3
Allopurinol11.3%311
4
Levothyroxine-sodium11.0%305
5
Metoprolol9.8%271
6
Aspirin9.2%255
7
Amlodipine8.2%227
8
Omeprazole7.5%206
9
Ondansetron7.2%198
10
Furosemide7.2%198
11
Gabapentin7.0%193
12
Folic-acid6.3%175
13
Cyanocobalamin6.2%171
14
Atorvastatin-calcium6.2%171
15
Tamsulosin-hydrochloride6.2%170

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports pacritinib side effects

17.8% of pacritinib adverse event reports involve female patients and 22.4% involve male patients. The largest age group is elderly at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.8%
Male22.4%
Unknown59.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6421.7%
65+78.3%

What is pacritinib used for

Conditions and purposes for which patients were taking pacritinib when the adverse event was reported.

5q Minus SyndromeAcute Myeloid LeukaemiaAcute Myelomonocytic LeukaemiaAnaemiaAnaemia Vitamin B12 DeficiencyAntiphospholipid SyndromeAplastic AnaemiaAttention Deficit Hyperactivity DisorderAutoinflammatory DiseaseBenign Prostatic HyperplasiaBladder CancerBone Marrow FailureBreast CancerBreast Cancer FemaleChronic Kidney Disease

Showing 15 of 76 indications

Pacritinib brand names and reporting trend

Pacritinib is sold under the brand name Vonjo.

Brand names

Vonjo119

Quarterly reports (20162025)

201620242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking pacritinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.