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Oxymorphone Side Effects

The most commonly reported side effects of oxymorphone include death, overdose, and toxicity to various agents, based on 43,613 FDA adverse event reports from 2004 to 2025. 1.7% of reports found the drug to be ineffective.

Oxymorphone side effects

Percentages show how often each reaction appears relative to total reports for oxymorphone.

1
Death30.8%13,427
2
Overdose22.8%9,933
3
Toxicity To Various Agents22.3%9,713
4
Dependence20.2%8,826
5
Drug Dependence8.8%3,834
6
Drug Abuse5.6%2,439
7
Drug Withdrawal Syndrome Neonatal4.8%2,092
8
Ill-defined Disorder4.3%1,883
9
Pain3.7%1,601
10
Foetal Exposure During Pregnancy2.7%1,168
11
Emotional Distress2.2%972
12
Drug Withdrawal Syndrome2.1%907
13
Withdrawal Syndrome2.0%858
14
Drug Ineffective1.7%722
15
Accidental Overdose1.6%680

These are voluntary reports and do not establish that oxymorphone caused these reactions.

Report severity

93.0%Serious40,574 reports
8.3%Hospitalizations3,629 reports
53.4%Fatal23,309 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxymorphone drug interactions

Other drugs that appear in adverse event reports alongside oxymorphone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxycodone75.5%32,943
2
Acetaminophen71.6%31,237
3
Morphine-sulfate62.3%27,167
4
Fentanyl59.9%26,137
5
Hydrocodone58.4%25,449
6
Hydromorphone-hydrochloride57.8%25,225
7
Buprenorphine54.7%23,847
8
Aspirin54.6%23,833
9
Tapentadol51.8%22,597
10
Ibuprofen16.9%7,372
11
Tramadol-hydrochloride12.9%5,611
12
Promethazine-hydrochloride7.0%3,070
13
Codeine7.0%3,055
14
Propoxyphene6.7%2,933
15
Methadone-hydrochloride3.7%1,604

Taken alongside

1
Oxycodone2.5%1,093
2
Acetaminophen1.9%821
3
Gabapentin1.5%645
4
Alprazolam1.1%482
5
Ergocalciferol1.1%476
6
Levothyroxine-sodium1.0%439
7
Duloxetine-hydrochloride1.0%438
8
Aspirin1.0%426
9
Pregabalin0.9%397
10
Hydrocodone0.9%386
11
Lisinopril0.9%376
12
Albuterol0.9%376
13
Omeprazole0.8%362
14
Clonazepam0.8%349
15
Tizanidine-hydrochloride0.7%323

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxymorphone side effects

17.1% of oxymorphone adverse event reports involve female patients and 18.4% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.1%
Male18.4%
Unknown64.6%

Age group

< 214.0%
2–111.0%
12–171.1%
18–6475.0%
65+8.9%

What is oxymorphone used for

Conditions and purposes for which patients were taking oxymorphone when the adverse event was reported.

Abdominal PainAccidentAccidental ExposureAccidental OverdoseAccidental PoisoningAdnexa Uteri PainAnalgesiaAnalgesic TherapyAngerAngiopathyAnkle FractureAnkylosing SpondylitisAnxietyArachnoiditisArthralgia

Showing 15 of 275 indications

Oxymorphone brand names and reporting trend

Oxymorphone is sold under the brand name Opana Er.

Brand names

Opana Er2

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxymorphone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.