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Oxygen Side Effects

The most commonly reported side effects of oxygen include dyspnoea, cough, and headache, based on 47,650 FDA adverse event reports from 2004 to 2025. 3.3% of reports found the drug to be ineffective.

Oxygen side effects

Percentages show how often each reaction appears relative to total reports for oxygen.

1
Dyspnoea17.3%8,256
2
Cough8.7%4,122
3
Headache8.5%4,052
4
Diarrhoea7.7%3,668
5
Fatigue7.4%3,548
6
Nausea7.0%3,354
7
Pneumonia6.9%3,308
8
Dizziness6.0%2,854
9
Oxygen Saturation Decreased5.6%2,653
10
Death4.5%2,161
11
Off Label Use4.5%2,150
12
Malaise4.3%2,033
13
Asthenia4.1%1,973
14
Hypotension4.0%1,923
15
Weight Decreased3.8%1,805

These are voluntary reports and do not establish that oxygen caused these reactions.

Report severity

69.1%Serious32,929 reports
43.5%Hospitalizations20,706 reports
15.7%Fatal7,461 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxygen drug interactions

Other drugs that appear in adverse event reports alongside oxygen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Treprostinil28.8%13,710
2
Ambrisentan5.7%2,694
3
Macitentan5.2%2,468
4
Bosentan3.5%1,691
5
Fluticasone3.3%1,592
6
Riociguat2.6%1,260
7
Tiotropium-bromide2.4%1,152
8
Salmeterol-xinafoate2.3%1,103
9
Selexipag2.2%1,048
10
Albuterol2.2%1,042
11
Sotatercept-csrk1.9%909
12
Budesonide1.8%872
13
Sildenafil-citrate1.8%847
14
Tadalafil1.8%837
15
Nintedanib1.6%772

Taken alongside

1
Albuterol29.1%13,844
2
Furosemide27.9%13,271
3
Acetaminophen23.0%10,946
4
Aspirin19.6%9,351
5
Fluticasone18.8%8,969
6
Ergocalciferol18.5%8,794
7
Potassium-chloride14.8%7,066
8
Omeprazole14.2%6,763
9
Prednisone14.2%6,760
10
Spironolactone13.7%6,550
11
Atorvastatin-calcium13.7%6,535
12
Sildenafil-citrate13.6%6,503
13
Levothyroxine-sodium13.2%6,292
14
Gabapentin11.7%5,569
15
Metoprolol11.4%5,440

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxygen side effects

61.0% of oxygen adverse event reports involve female patients and 33.3% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.0%
Male33.3%
Unknown5.7%

Age group

< 22.1%
2–112.0%
12–171.3%
18–6440.4%
65+54.1%

What is oxygen used for

Conditions and purposes for which patients were taking oxygen when the adverse event was reported.

Accidental Exposure To ProductAcute Myocardial InfarctionAcute Pulmonary OedemaAcute Respiratory Distress SyndromeAcute Respiratory FailureAdjuvant TherapyAdverse EventAgitationAir EmbolismAlpha-1 Anti-trypsin DeficiencyAlveolar Oxygen Partial Pressure DecreasedAlveolitis AllergicAnaemiaAnaesthesiaAnaesthesia Procedure

Showing 15 of 725 indications

Oxygen brand names and reporting trend

Oxygen is sold under the brand name Oxygen, Usp.

Brand names

Oxygen, Usp52,419

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxygen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.