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Oxybutynin Side Effects

The most commonly reported side effects of oxybutynin include fatigue, fall, and nausea, based on 46,445 FDA adverse event reports from 2004 to 2025. 10.6% of reports found the drug to be ineffective.

Oxybutynin side effects

Percentages show how often each reaction appears relative to total reports for oxybutynin.

1
Drug Ineffective10.6%4,928
2
Fatigue5.4%2,492
3
Fall4.9%2,257
4
Nausea4.0%1,878
5
Off Label Use3.9%1,790
6
Diarrhoea3.6%1,689
7
Headache3.6%1,662
8
Urinary Tract Infection3.6%1,652
9
Pain3.5%1,622
10
Dizziness3.4%1,591
11
Asthenia2.9%1,343
12
Pruritus2.7%1,245
13
Constipation2.6%1,205
14
Gait Disturbance2.6%1,185
15
Malaise2.3%1,080

These are voluntary reports and do not establish that oxybutynin caused these reactions.

Report severity

53.2%Serious24,718 reports
27.4%Hospitalizations12,714 reports
6.3%Fatal2,942 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxybutynin drug interactions

Other drugs that appear in adverse event reports alongside oxybutynin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfampridine5.6%2,606
2
Interferon3.1%1,423
3
Dimethyl3.0%1,404
4
Lenalidomide2.7%1,266
5
Adalimumab2.6%1,204
6
Omeprazole1.9%883
7
Sodium-oxybate1.8%835
8
Fingolimod1.6%765
9
Pregabalin1.6%745
10
Esomeprazole1.6%739
11
Pantoprazole-sodium1.5%682
12
Natalizumab1.4%659
13
Teriflunomide1.3%624
14
Acetaminophen1.3%605
15
Ocrelizumab1.3%585

Taken alongside

1
Ergocalciferol17.4%8,093
2
Acetaminophen16.8%7,805
3
Aspirin15.6%7,232
4
Gabapentin14.7%6,820
5
Levothyroxine-sodium14.4%6,708
6
Omeprazole13.7%6,373
7
Atorvastatin-calcium11.7%5,452
8
Lisinopril9.7%4,500
9
Amlodipine9.7%4,491
10
Albuterol9.7%4,484
11
Furosemide9.6%4,474
12
Baclofen9.5%4,403
13
Metoprolol9.4%4,371
14
Metformin8.8%4,068
15
Calcium7.6%3,542

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxybutynin side effects

71.7% of oxybutynin adverse event reports involve female patients and 23.0% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.7%
Male23.0%
Unknown5.4%

Age group

< 20.3%
2–111.4%
12–170.7%
18–6446.9%
65+50.8%

What is oxybutynin used for

Conditions and purposes for which patients were taking oxybutynin when the adverse event was reported.

Abdominal DiscomfortAbdominal InfectionAbdominal Pain UpperAbdominal RigidityAccidentAccidental Drug Intake By ChildAccidental ExposureAccidental OverdoseAdverse EventAlcoholismAnaemiaAnal IncontinenceAnalgesic TherapyAntibiotic TherapyAnxiety

Showing 15 of 406 indications

Oxybutynin brand names and reporting trend

Oxybutynin is sold under brand names including Gelnique 3%, Oxybutynin Chloride.

Brand names

Gelnique 3%24,104
Oxybutynin Chloride9,532

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxybutynin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.