OpenClaim

Oxybenzone Side Effects

The most commonly reported side effects of oxybenzone include headache, abdominal pain upper, and off label use, based on 31 FDA adverse event reports from 2004 to 2025.

Oxybenzone side effects

Percentages show how often each reaction appears relative to total reports for oxybenzone.

1
Headache16.1%5
2
Abdominal Pain Upper12.9%4
3
Off Label Use12.9%4
4
Nausea12.9%4
5
Peripheral Swelling9.7%3
6
Fluid Retention9.7%3
7
Diarrhoea9.7%3
8
Bone Pain9.7%3
9
Pruritus9.7%3
10
Migraine9.7%3
11
Pain9.7%3
12
Balance Disorder9.7%3
13
Confusional State9.7%3
14
Fall9.7%3
15
Skin Cancer6.5%2

These are voluntary reports and do not establish that oxybenzone caused these reactions.

Report severity

74.2%Serious23 reports
29.0%Hospitalizations9 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxybenzone drug interactions

Other drugs that appear in adverse event reports alongside oxybenzone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ruxolitinib12.9%4
2
Dupilumab12.9%4
3
Teriparatide9.7%3
4
Folic-acid6.5%2
5
Acetaminophen6.5%2
6
Ustekinumab6.5%2
7
Simvastatin3.2%1
8
Atenolol3.2%1
9
Candesartan-cilexetil3.2%1
10
Flurbiprofen3.2%1
11
Isosorbide3.2%1
12
Lansoprazole3.2%1
13
Methotrexate3.2%1
14
Adalimumab3.2%1
15
Diphenhydramine3.2%1

Taken alongside

1
Omeprazole38.7%12
2
Fluticasone29.0%9
3
Clobetasol-propionate29.0%9
4
Avobenzone25.8%8
5
Octinoxate25.8%8
6
Dexamethasone25.8%8
7
Gabapentin25.8%8
8
Rosuvastatin22.6%7
9
Ibuprofen22.6%7
10
Acetaminophen22.6%7
11
Albuterol22.6%7
12
Budesonide19.4%6
13
Mirtazapine19.4%6
14
Acyclovir19.4%6
15
Tramadol-hydrochloride19.4%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxybenzone side effects

51.6% of oxybenzone adverse event reports involve female patients and 35.5% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.6%
Male35.5%
Unknown12.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6456.5%
65+43.5%

What is oxybenzone used for

Conditions and purposes for which patients were taking oxybenzone when the adverse event was reported.

Dry SkinDiarrhoeaGastrointestinal DisorderProduct Used For Unknown IndicationProduct Used For Unknown IndicationProphylaxisSkin Disorder

Oxybenzone brand names and reporting trend

Oxybenzone is sold under the brand name Shade Uvaguard.

Brand names

Shade Uvaguard25

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxybenzone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.