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Oxaprozin Side Effects

The most commonly reported side effects of oxaprozin include drug hypersensitivity, chronic kidney disease, and pain, based on 2,143 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Oxaprozin side effects

Percentages show how often each reaction appears relative to total reports for oxaprozin.

1
Drug Hypersensitivity17.6%378
2
Drug Ineffective5.5%118
3
Chronic Kidney Disease4.8%103
4
Pain3.9%83
5
Nausea3.6%77
6
Headache3.4%72
7
Pain3.2%68
8
Renal Failure3.2%68
9
Acute Kidney Injury3.0%65
10
Fatigue2.9%62
11
Nausea2.8%61
12
Drug Ineffective2.8%61
13
Arthralgia2.8%59
14
Rash2.5%54
15
Pain In Extremity2.3%49

These are voluntary reports and do not establish that oxaprozin caused these reactions.

Report severity

50.5%Serious1,083 reports
24.2%Hospitalizations519 reports
3.7%Fatal79 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxaprozin drug interactions

Other drugs that appear in adverse event reports alongside oxaprozin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab10.0%214
2
Etanercept6.6%141
3
Esomeprazole5.6%121
4
Omeprazole5.3%114
5
Pantoprazole-sodium3.9%84
6
Lansoprazole3.8%82
7
Celecoxib3.3%71
8
Gabapentin3.0%65
9
Naproxen3.0%65
10
Acetaminophen2.8%61
11
Ibuprofen2.8%60
12
Sodium-oxybate2.7%58
13
Rofecoxib2.5%53
14
Oxycodone2.2%48
15
Pregabalin2.1%45

Taken alongside

1
Acetaminophen18.7%401
2
Aspirin13.1%281
3
Gabapentin11.9%256
4
Levothyroxine-sodium11.7%250
5
Hydrocodone11.3%242
6
Tramadol-hydrochloride11.0%235
7
Hydrochlorothiazide10.6%228
8
Omeprazole10.3%220
9
Ergocalciferol10.2%219
10
Lisinopril10.1%216
11
Prednisone9.7%208
12
Methotrexate9.3%199
13
Albuterol9.1%196
14
Atorvastatin-calcium8.9%191
15
Ibuprofen8.6%185

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxaprozin side effects

70.9% of oxaprozin adverse event reports involve female patients and 24.2% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female70.9%
Male24.2%
Unknown4.9%

Age group

< 2<0.1%
2–11<0.1%
12–170.2%
18–6467.6%
65+32.0%

What is oxaprozin used for

Conditions and purposes for which patients were taking oxaprozin when the adverse event was reported.

Analgesic Intervention Supportive TherapyAngina PectorisAnkylosing SpondylitisAntiinflammatory TherapyArthralgiaArthritisArthropathyAnalgesic TherapyAntibiotic TherapyAntiinflammatory TherapyArthralgiaArthritisArthritis ReactiveBack DisorderBack Pain

Showing 15 of 99 indications

Oxaprozin brand names and reporting trend

Oxaprozin is sold under brand names including Coxanto, Daypro Alta.

Brand names

Coxanto944
Daypro Alta72

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxaprozin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.