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Oxaliplatin Side Effects

The most commonly reported side effects of oxaliplatin include diarrhoea, nausea, and off label use, based on 81,820 FDA adverse event reports from 2004 to 2025. 2.5% of reports found the drug to be ineffective.

Oxaliplatin side effects

Percentages show how often each reaction appears relative to total reports for oxaliplatin.

1
Diarrhoea7.5%6,141
2
Nausea6.3%5,174
3
Off Label Use5.7%4,666
4
Neuropathy Peripheral5.2%4,225
5
Vomiting5.0%4,103
6
Disease Progression5.0%4,095
7
Neutropenia4.9%3,981
8
Thrombocytopenia4.1%3,355
9
Dyspnoea3.7%3,054
10
Pyrexia3.3%2,694
11
Fatigue3.1%2,565
12
Asthenia2.8%2,327
13
Anaemia2.8%2,282
14
Death2.5%2,064
15
Drug Ineffective2.5%2,051

These are voluntary reports and do not establish that oxaliplatin caused these reactions.

Report severity

96.5%Serious78,916 reports
41.2%Hospitalizations33,706 reports
14.1%Fatal11,533 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxaliplatin drug interactions

Other drugs that appear in adverse event reports alongside oxaliplatin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fluorouracil39.5%32,285
2
Bevacizumab20.8%17,020
3
Capecitabine19.5%15,967
4
Irinotecan-hydrochloride14.0%11,444
5
Levoleucovorin10.8%8,802
6
Leucovorin-calcium8.2%6,747
7
Gemcitabine7.8%6,409
8
Panitumumab6.0%4,924
9
Rituximab4.8%3,921
10
Cetuximab4.8%3,898
11
Calcium3.9%3,165
12
Dexamethasone3.3%2,698
13
Doxorubicin-hydrochloride3.2%2,619
14
Cyclophosphamide3.1%2,575
15
Docetaxel3.1%2,512

Taken alongside

1
Fluorouracil10.9%8,885
2
Dexamethasone7.6%6,250
3
Ondansetron5.6%4,580
4
Levoleucovorin5.4%4,390
5
Irinotecan-hydrochloride3.7%3,011
6
Capecitabine3.7%2,995
7
Acetaminophen3.4%2,804
8
Pantoprazole-sodium2.8%2,289
9
Leucovorin-calcium2.8%2,271
10
Omeprazole2.6%2,165
11
Bevacizumab2.4%1,987
12
Calcium2.3%1,866
13
Metoclopramide-hydrochloride2.2%1,800
14
Loperamide-hydrochloride2.2%1,782
15
Palonosetron-hydrochloride1.9%1,518

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxaliplatin side effects

35.7% of oxaliplatin adverse event reports involve female patients and 50.2% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.7%
Male50.2%
Unknown14.2%

Age group

< 20.2%
2–110.1%
12–170.3%
18–6454.3%
65+45.1%

What is oxaliplatin used for

Conditions and purposes for which patients were taking oxaliplatin when the adverse event was reported.

Abdominal NeoplasmAccidental ExposureAcinar Cell Carcinoma Of PancreasAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of AppendixAdenocarcinoma Of ColonAdenocarcinoma Of Colon Stage IiiAdenocarcinoma Of The Gastroesophageal JunctionAdenocarcinoma PancreasAdenoid Cystic CarcinomaAdenomatous Polyposis Coli

Showing 15 of 1,269 indications

Oxaliplatin brand names and reporting trend

Oxaliplatin is sold under the brand name Oxaliplatin.

Brand names

Oxaliplatin93,506

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxaliplatin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.