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Oxacillin Side Effects

The most commonly reported side effects of oxacillin include drug interaction, rhabdomyolysis, and renal failure acute, based on 712 FDA adverse event reports from 2004 to 2025.

Oxacillin side effects

Percentages show how often each reaction appears relative to total reports for oxacillin.

1
Drug Interaction7.2%51
2
Rhabdomyolysis6.0%43
3
Renal Failure Acute5.6%40
4
Diarrhoea4.2%30
5
Metabolic Acidosis3.7%26
6
Malaise2.8%20
7
Rash2.7%19
8
Dizziness2.2%16
9
Renal Impairment2.2%16
10
Vomiting2.2%16
11
Abdominal Pain2.2%16
12
Alanine Aminotransferase Increased2.1%15
13
Nausea2.1%15
14
Pyroglutamate Increased2.1%15
15
Drug Reaction With Eosinophilia And Systemic Symptoms2.1%15

These are voluntary reports and do not establish that oxacillin caused these reactions.

Report severity

95.5%Serious680 reports
51.1%Hospitalizations364 reports
14.0%Fatal100 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oxacillin drug interactions

Other drugs that appear in adverse event reports alongside oxacillin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Simvastatin6.3%45
2
Acetaminophen5.9%42
3
Clindamycin4.6%33
4
Ciprofloxacin3.9%28
5
Gentamicin-sulfate3.5%25
6
Daptomycin3.1%22
7
Ceftriaxone-sodium2.7%19
8
Amoxicillin2.4%17
9
Vancomycin2.4%17
10
Rifampin2.2%16
11
Levetiracetam2.0%14
12
Diclofenac1.8%13
13
Methotrexate1.8%13
14
Dexamethasone1.8%13
15
Warfarin1.8%13

Taken alongside

1
Acetaminophen20.6%147
2
Omeprazole13.2%94
3
Aspirin11.1%79
4
Furosemide10.3%73
5
Lansoprazole7.4%53
6
Amoxicillin6.7%48
7
Hydrochlorothiazide6.5%46
8
Folic-acid6.3%45
9
Simvastatin6.2%44
10
Albuterol5.9%42
11
Metformin5.8%41
12
Ramipril5.8%41
13
Amlodipine4.9%35
14
Penicillin4.6%33
15
Bisoprolol-fumarate4.6%33

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oxacillin side effects

42.6% of oxacillin adverse event reports involve female patients and 52.0% involve male patients. The largest age group is elderly at 45%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.6%
Male52.0%
Unknown5.5%

Age group

< 22.3%
2–115.3%
12–172.5%
18–6444.6%
65+45.4%

What is oxacillin used for

Conditions and purposes for which patients were taking oxacillin when the adverse event was reported.

AbscessAbscess LimbAcarodermatitisAcneAntibiotic ProphylaxisAntibiotic TherapyArthritisArthritis BacterialArthritis InfectiveAbscessAntibiotic TherapyArthritis InfectiveBacterial InfectionBlister InfectedBreast Engorgement

Showing 15 of 113 indications

Oxacillin brand names and reporting trend

Oxacillin is sold under the brand name Bactocill.

Brand names

Bactocill696

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oxacillin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.