OpenClaim

Oritavancin Side Effects

The most commonly reported side effects of oritavancin include off label use, pruritus, and chills, based on 1,184 FDA adverse event reports from 2014 to 2025. 4.1% of reports found the drug to be ineffective.

Oritavancin side effects

Percentages show how often each reaction appears relative to total reports for oritavancin.

1
Off Label Use18.7%221
2
Pruritus16.8%199
3
Chills14.4%171
4
Multiple Use Of Single-use Product10.5%124
5
Infusion Related Reaction10.4%123
6
Back Pain10.3%122
7
Urticaria9.9%117
8
Dyspnoea9.2%109
9
Rash9.2%109
10
Nausea8.4%100
11
Chest Pain6.5%77
12
Erythema6.4%76
13
Flushing6.3%75
14
Tremor5.8%69
15
Vomiting5.3%63

These are voluntary reports and do not establish that oritavancin caused these reactions.

Report severity

35.9%Serious425 reports
16.2%Hospitalizations192 reports
3.0%Fatal35 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oritavancin drug interactions

Other drugs that appear in adverse event reports alongside oritavancin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Daptomycin2.4%29
2
Vancomycin1.3%15
3
Lansoprazole1.0%12
4
Cetirizine-hydrochloride1.0%12
5
Enoxaparin-sodium1.0%12
6
Oxazepam1.0%12
7
Morphine-sulfate1.0%12
8
Ceftaroline-fosamil0.8%9
9
Tigecycline0.6%7
10
Acetaminophen0.6%7
11
Linezolid0.6%7
12
Ceftriaxone-sodium0.5%6
13
Diphenhydramine0.5%6
14
Ampicillin0.5%6
15
Ondansetron0.4%5

Taken alongside

1
Diphenhydramine5.5%65
2
Acetaminophen3.8%45
3
Vancomycin3.0%36
4
Furosemide2.8%33
5
Gabapentin2.1%25
6
Metformin2.0%24
7
Omeprazole1.9%23
8
Potassium-chloride1.9%23
9
Sulfamethoxazole1.8%21
10
Trimethoprim1.8%21
11
Daptomycin1.8%21
12
Ondansetron1.8%21
13
Insulin1.7%20
14
Spironolactone1.6%19
15
Aspirin1.5%18

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oritavancin side effects

34.5% of oritavancin adverse event reports involve female patients and 33.8% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.5%
Male33.8%
Unknown31.7%

Age group

< 20.0%
2–110.0%
12–170.8%
18–6464.2%
65+35.1%

What is oritavancin used for

Conditions and purposes for which patients were taking oritavancin when the adverse event was reported.

AbscessAbscess LimbActinomycosisAnimal BiteAntibiotic TherapyArthritis BacterialArthritis InfectiveArthropod BiteAbdominal Wall InfectionAbdominal Wall WoundAbscessAbscess DrainageAbscess LimbAlpha Haemolytic Streptococcal InfectionAntibiotic Therapy

Showing 15 of 154 indications

Oritavancin brand names and reporting trend

Oritavancin is sold under the brand name Kimyrsa.

Brand names

Kimyrsa190

Quarterly reports (20142025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oritavancin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.