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Opicapone Side Effects

The most commonly reported side effects of opicapone include hallucination, dyskinesia, and fall, based on 1,997 FDA adverse event reports from 2008 to 2025. 5.6% of reports found the drug to be ineffective.

Opicapone side effects

Percentages show how often each reaction appears relative to total reports for opicapone.

1
Hallucination13.6%271
2
Dyskinesia13.1%262
3
Fall11.0%219
4
Tremor6.3%126
5
Death6.2%124
6
Gait Disturbance5.8%115
7
Parkinson^s Disease5.7%113
8
Drug Ineffective5.6%112
9
Confusional State5.5%109
10
On And Off Phenomenon5.2%104
11
Constipation4.8%95
12
Anxiety4.7%93
13
Fatigue4.6%92
14
Dizziness4.5%89
15
Hallucination, Visual4.1%82

These are voluntary reports and do not establish that opicapone caused these reactions.

Report severity

73.0%Serious1,457 reports
38.9%Hospitalizations776 reports
10.6%Fatal211 reports

Seriousness is determined by the reporter, not by OpenClaim.

Opicapone drug interactions

Other drugs that appear in adverse event reports alongside opicapone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levodopa23.4%468
2
Carbidopa19.4%388
3
Pimavanserin4.2%84
4
Entacapone2.9%58
5
Amantadine2.8%55
6
Istradefylline2.8%55
7
Rasagiline-mesylate2.7%54
8
Rotigotine2.6%51
9
Safinamide2.5%50
10
Pramipexole-dihydrochloride2.5%49
11
Ropinirole-hydrochloride1.7%34
12
Mirtazapine1.6%31
13
Apomorphine-hydrochloride1.6%31
14
Quetiapine-fumarate1.3%25
15
Rivastigmine1.1%22

Taken alongside

1
Levodopa37.9%756
2
Carbidopa31.1%621
3
Amantadine8.5%170
4
Aspirin8.3%165
5
Quetiapine-fumarate8.2%163
6
Rasagiline-mesylate7.3%146
7
Rotigotine6.8%136
8
Pantoprazole-sodium6.8%135
9
Pramipexole-dihydrochloride6.3%125
10
Ropinirole-hydrochloride6.2%123
11
Cyanocobalamin5.9%117
12
Safinamide5.8%116
13
Levothyroxine-sodium5.6%112
14
Ergocalciferol5.5%110
15
Atorvastatin-calcium5.4%108

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports opicapone side effects

23.2% of opicapone adverse event reports involve female patients and 35.2% involve male patients. The largest age group is elderly at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.2%
Male35.2%
Unknown41.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6420.5%
65+79.5%

What is opicapone used for

Conditions and purposes for which patients were taking opicapone when the adverse event was reported.

Adjuvant TherapyAdjuvant TherapyAdverse Drug ReactionBradykinesiaCataractCondition AggravatedConstipationDrug Use For Unknown IndicationDyskinesiaDiabetes MellitusEye DisorderIll-defined DisorderMacular DegenerationMalabsorptionMultiple System Atrophy

Showing 15 of 29 indications

Opicapone brand names and reporting trend

Opicapone is sold under the brand name Ongentys.

Brand names

Ongentys498

Quarterly reports (20082025)

200820202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking opicapone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.