OpenClaim

Omadacycline Side Effects

The most commonly reported side effects of omadacycline include off label use, nausea, and vomiting, based on 1,485 FDA adverse event reports from 2018 to 2025. 7.6% of reports found the drug to be ineffective.

Omadacycline side effects

Percentages show how often each reaction appears relative to total reports for omadacycline.

1
Off Label Use27.4%407
2
Nausea16.6%246
3
Vomiting10.2%152
4
Drug Ineffective7.6%113
5
Diarrhoea7.2%107
6
Incorrect Product Administration Duration5.1%76
7
Rash4.8%71
8
Incorrect Dose Administered4.6%68
9
Death4.4%66
10
Dyspnoea4.4%66
11
Fatigue3.8%56
12
Hospitalisation3.7%55
13
Headache3.6%53
14
Pruritus3.5%52
15
Drug Ineffective For Unapproved Indication3.2%48

These are voluntary reports and do not establish that omadacycline caused these reactions.

Report severity

54.7%Serious812 reports
22.4%Hospitalizations333 reports
6.9%Fatal102 reports

Seriousness is determined by the reporter, not by OpenClaim.

Omadacycline drug interactions

Other drugs that appear in adverse event reports alongside omadacycline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Amikacin-sulfate15.7%233
2
Azithromycin11.6%172
3
Linezolid8.8%130
4
Clofazimine8.2%122
5
Imipenem8.2%122
6
Tedizolid-phosphate4.2%63
7
Tigecycline2.6%39
8
Ethambutol-hydrochloride2.6%39
9
Moxifloxacin-hydrochloride2.4%36
10
Cilastatin-sodium2.3%34
11
Cefoxitin-sodium2.0%30
12
Levofloxacin2.0%29
13
Meropenem1.8%26
14
Doxycycline1.8%26
15
Clarithromycin1.5%22

Taken alongside

1
Amikacin-sulfate7.7%114
2
Azithromycin7.6%113
3
Clofazimine5.7%84
4
Albuterol4.6%69
5
Ergocalciferol4.2%63
6
Levothyroxine-sodium4.2%62
7
Atorvastatin-calcium3.9%58
8
Aspirin3.9%58
9
Imipenem3.7%55
10
Linezolid3.6%53
11
Acetaminophen3.5%52
12
Metoprolol3.4%51
13
Omeprazole3.2%48
14
Ondansetron3.2%47
15
Gabapentin3.1%46

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports omadacycline side effects

49.4% of omadacycline adverse event reports involve female patients and 40.1% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.4%
Male40.1%
Unknown10.5%

Age group

< 20.0%
2–110.1%
12–172.8%
18–6452.6%
65+44.5%

What is omadacycline used for

Conditions and purposes for which patients were taking omadacycline when the adverse event was reported.

Abdominal InfectionAbscessAbscess BacterialAbscess LimbAcinetobacter InfectionAcute SinusitisAntimicrobial Susceptibility Test ResistantAsthmaAtypical Mycobacterial Lower Respiratory Tract InfectionAbdominal InfectionAbdominal Wall AbscessAbdominal Wall WoundAbscessAbscess BacterialAbscess Limb

Showing 15 of 240 indications

Omadacycline brand names and reporting trend

Omadacycline is sold under the brand name Nuzyra.

Brand names

Nuzyra497

Quarterly reports (20182025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking omadacycline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.