OpenClaim

Omacetaxine Side Effects

The most commonly reported side effects of omacetaxine include myelosuppression, nausea, and platelet count decreased, based on 1,070 FDA adverse event reports from 2008 to 2025. 3.8% of reports found the drug to be ineffective.

Omacetaxine side effects

Percentages show how often each reaction appears relative to total reports for omacetaxine.

1
Myelosuppression18.2%195
2
Nausea14.2%152
3
Platelet Count Decreased10.1%108
4
Fatigue7.5%80
5
Diarrhoea7.1%76
6
White Blood Cell Count Decreased6.9%74
7
Pyrexia6.7%72
8
Injection Site Erythema6.0%64
9
Vomiting5.6%60
10
Death5.6%60
11
Asthenia5.4%58
12
Headache4.6%49
13
Neutropenia4.5%48
14
Haemoglobin Decreased3.9%42
15
Drug Ineffective3.8%41

These are voluntary reports and do not establish that omacetaxine caused these reactions.

Report severity

70.2%Serious751 reports
33.9%Hospitalizations363 reports
9.4%Fatal101 reports

Seriousness is determined by the reporter, not by OpenClaim.

Omacetaxine drug interactions

Other drugs that appear in adverse event reports alongside omacetaxine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cytarabine23.6%253
2
Venetoclax17.4%186
3
Azacitidine12.8%137
4
Decitabine5.6%60
5
Idarubicin-hydrochloride3.5%37
6
Dasatinib2.3%25
7
Ponatinib-hydrochloride2.3%25
8
Imatinib-mesylate2.2%24
9
Nilotinib1.7%18
10
Etoposide1.7%18
11
Filgrastim1.6%17
12
Bosutinib-monohydrate1.2%13
13
Methotrexate1.2%13
14
Hydroxyurea1.1%12
15
Cyclophosphamide1.1%12

Taken alongside

1
Furosemide8.0%86
2
Ondansetron7.9%85
3
Acetaminophen7.4%79
4
Allopurinol7.3%78
5
Oxycodone6.7%72
6
Aspirin6.5%70
7
Ergocalciferol6.0%64
8
Metoprolol5.9%63
9
Levothyroxine-sodium5.4%58
10
Atorvastatin-calcium5.0%53
11
Dextrose4.9%52
12
Amlodipine4.8%51
13
Hydroxyurea4.6%49
14
Metformin4.1%44
15
Sodium-chloride3.9%42

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports omacetaxine side effects

45.3% of omacetaxine adverse event reports involve female patients and 47.6% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.3%
Male47.6%
Unknown7.1%

Age group

< 20.5%
2–114.0%
12–172.9%
18–6461.7%
65+30.9%

What is omacetaxine used for

Conditions and purposes for which patients were taking omacetaxine when the adverse event was reported.

Acute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAcute Myeloid Leukaemia RefractoryAcute Promyelocytic LeukaemiaAllogenic Stem Cell TransplantationB-cell Type Acute LeukaemiaBone Marrow Conditioning RegimenChemotherapyChronic Leukaemia

Showing 15 of 57 indications

Omacetaxine brand names and reporting trend

Omacetaxine is sold under the brand name Synribo.

Brand names

Synribo456

Quarterly reports (20082025)

2008201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking omacetaxine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.