OpenClaim

Olopatadine Side Effects

The most commonly reported side effects of olopatadine include treatment failure, eye irritation, and headache, based on 15,664 FDA adverse event reports from 2004 to 2025. 10.9% of reports found the drug to be ineffective.

Olopatadine side effects

Percentages show how often each reaction appears relative to total reports for olopatadine.

1
Treatment Failure27.6%4,330
2
Drug Ineffective10.9%1,712
3
Eye Irritation3.6%564
4
Headache3.4%539
5
Fatigue3.0%472
6
Product Use In Unapproved Indication2.9%457
7
Nausea2.9%454
8
Vision Blurred2.4%373
9
Hypersensitivity2.3%365
10
Diarrhoea2.3%364
11
Dyspnoea2.3%362
12
Pain2.2%352
13
Device Delivery System Issue2.2%351
14
Eye Pruritus2.2%340
15
Pruritus2.2%338

These are voluntary reports and do not establish that olopatadine caused these reactions.

Report severity

31.1%Serious4,877 reports
14.2%Hospitalizations2,218 reports
2.7%Fatal427 reports

Seriousness is determined by the reporter, not by OpenClaim.

Olopatadine drug interactions

Other drugs that appear in adverse event reports alongside olopatadine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ketotifen-fumarate14.2%2,218
2
Azelastine7.6%1,189
3
Mometasone-furoate7.2%1,121
4
Dupilumab4.3%674
5
Epinastine-hydrochloride3.6%570
6
Sodium-oxybate3.5%542
7
Cromolyn-sodium3.4%533
8
Ketorolac-tromethamine2.0%311
9
Lenalidomide1.6%257
10
Omalizumab1.6%247
11
Adalimumab1.1%178
12
Prednisone1.1%177
13
Prednisolone1.0%155
14
Omeprazole0.9%142
15
Esomeprazole0.9%138

Taken alongside

1
Fluticasone14.5%2,268
2
Albuterol13.2%2,060
3
Acetaminophen11.4%1,788
4
Montelukast-sodium10.8%1,692
5
Ergocalciferol10.7%1,670
6
Cetirizine-hydrochloride7.8%1,214
7
Levothyroxine-sodium7.3%1,151
8
Aspirin7.3%1,147
9
Omeprazole7.1%1,105
10
Mometasone-furoate6.3%987
11
Prednisone5.9%931
12
Gabapentin5.8%916
13
Budesonide5.6%873
14
Furosemide5.5%862
15
Epinephrine5.4%848

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports olopatadine side effects

60.3% of olopatadine adverse event reports involve female patients and 25.1% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.3%
Male25.1%
Unknown14.6%

Age group

< 20.2%
2–113.2%
12–173.3%
18–6455.4%
65+37.9%

What is olopatadine used for

Conditions and purposes for which patients were taking olopatadine when the adverse event was reported.

Abdominal PainAbnormal Sensation In EyeAcute Lymphocytic LeukaemiaAcute SinusitisAdverse EventAge-related Macular DegenerationAllergic SinusitisAllergy ProphylaxisAllergy To AnimalAlopecia AreataAnaphylactic ReactionAntiallergic TherapyAsthmaAtopyAutoimmune Disorder

Showing 15 of 341 indications

Olopatadine brand names and reporting trend

Olopatadine is sold under the brand name Pataday Once Daily Relief.

Brand names

Pataday Once Daily Relief12

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking olopatadine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.