OpenClaim

Olipudase Side Effects

The most commonly reported side effects of olipudase include incorrect dose administered, nausea, and headache, based on 121 FDA adverse event reports from 2009 to 2025.

Olipudase side effects

Percentages show how often each reaction appears relative to total reports for olipudase.

1
Incorrect Dose Administered9.1%11
2
Nausea7.4%9
3
Headache7.4%9
4
Fatigue5.8%7
5
Weight Increased5.8%7
6
Pyrexia5.0%6
7
Vomiting4.1%5
8
Sinusitis4.1%5
9
Erythema4.1%5
10
Asthenia3.3%4
11
Chest Discomfort3.3%4
12
Condition Aggravated3.3%4
13
Heart Rate Increased3.3%4
14
Illness3.3%4
15
Urticaria3.3%4

These are voluntary reports and do not establish that olipudase caused these reactions.

Report severity

28.1%Serious34 reports
19.8%Hospitalizations24 reports
1.7%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Olipudase drug interactions

Other drugs that appear in adverse event reports alongside olipudase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ramipril3.3%4
2
Isosorbide2.5%3
3
Hydrochlorothiazide2.5%3
4
Daratumumab1.7%2
5
Carfilzomib1.7%2
6
Acetaminophen1.7%2
7
Cetirizine-hydrochloride1.7%2
8
Prednisone1.7%2
9
Betamethasone1.7%2
10
Albuterol1.7%2
11
Methylprednisolone1.7%2
12
Zoledronic-acid0.8%1
13
Abatacept0.8%1
14
Gemcitabine0.8%1
15
Paclitaxel0.8%1

Taken alongside

1
Sodium-chloride19.0%23
2
Epinephrine18.2%22
3
Diphenhydramine16.5%20
4
Sterile14.0%17
5
Acetaminophen11.6%14
6
Methylprednisolone5.8%7
7
Heparin5.8%7
8
Lidocaine5.0%6
9
Levothyroxine-sodium4.1%5
10
Cetirizine-hydrochloride4.1%5
11
Phenprocoumon3.3%4
12
Topiramate3.3%4
13
Ondansetron3.3%4
14
Ibuprofen2.5%3
15
Omeprazole2.5%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports olipudase side effects

57.9% of olipudase adverse event reports involve female patients and 31.4% involve male patients. The largest age group is adult at 42%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.9%
Male31.4%
Unknown10.7%

Age group

< 26.7%
2–1140.0%
12–174.8%
18–6441.9%
65+6.7%

What is olipudase used for

Conditions and purposes for which patients were taking olipudase when the adverse event was reported.

Niemann-pick DiseasePancreatic EnzymesProduct Used For Unknown Indication

Olipudase brand names and reporting trend

Olipudase is sold under the brand name Xenpozyme.

Brand names

Xenpozyme52

Quarterly reports (20092025)

200920242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking olipudase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.