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Oliceridine Side Effects

The most commonly reported side effects of oliceridine include respiratory failure, encephalopathy, and diaphragmatic paralysis, based on 3 FDA adverse event reports from 2021 to 2025.

Oliceridine side effects

Percentages show how often each reaction appears relative to total reports for oliceridine.

1
Respiratory Failure66.7%2
2
Encephalopathy66.7%2
3
Diaphragmatic Paralysis66.7%2
4
Toxicity To Various Agents66.7%2
5
Dependence On Respirator66.7%2
6
Respiratory Paralysis66.7%2
7
Neuromuscular Blockade66.7%2
8
Product Use In Unapproved Indication66.7%2
9
Respiratory Depression33.3%1

These are voluntary reports and do not establish that oliceridine caused these reactions.

Report severity

100.0%Serious3 reports
66.7%Hospitalizations2 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Oliceridine drug interactions

Other drugs that appear in adverse event reports alongside oliceridine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Polymyxin-b-sulfate66.7%2
2
Lorazepam33.3%1
3
Diazepam33.3%1
4
Zolpidem-tartrate33.3%1
5
Clonazepam33.3%1
6
Midazolam33.3%1
7
Temazepam33.3%1
8
Gabapentin33.3%1
9
Alprazolam33.3%1
10
Pregabalin33.3%1

Taken alongside

1
Piperacillin66.7%2
2
Tazobactam-sodium66.7%2
3
Meropenem66.7%2
4
Vancomycin66.7%2
5
Tigecycline66.7%2
6
Heparin66.7%2
7
Omeprazole66.7%2
8
Ibuprofen66.7%2
9
Nalbuphine-hydrochloride66.7%2
10
Sodium-chloride66.7%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports oliceridine side effects

66.7% of oliceridine adverse event reports involve female patients and 0.0% involve male patients. The largest age group is adult at 100%. These figures reflect who reports side effects, not underlying risk.

Sex

Female66.7%
Male0.0%
Unknown33.3%

Age group

< 20.0%
2–110.0%
12–170.0%
18–64100.0%
65+0.0%

What is oliceridine used for

Conditions and purposes for which patients were taking oliceridine when the adverse event was reported.

PainPain

Oliceridine brand names and reporting trend

Oliceridine is sold under the brand name Olinvyk.

Brand names

Olinvyk3

Quarterly reports (20212025)

20212025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking oliceridine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.