OpenClaim

Olezarsen Side Effects

The most commonly reported side effects of olezarsen include blood triglycerides increased, pancreatitis acute, and injection site pain, based on 145 FDA adverse event reports from 2024 to 2025.

Olezarsen side effects

Percentages show how often each reaction appears relative to total reports for olezarsen.

1
Blood Triglycerides Increased13.1%19
2
Pancreatitis Acute9.7%14
3
Injection Site Pain9.0%13
4
Injection Site Erythema7.6%11
5
Pancreatitis6.2%9
6
Injection Site Discolouration4.8%7
7
Off Label Use4.8%7
8
Abdominal Pain4.1%6
9
Arthralgia4.1%6
10
Product Dose Omission Issue4.1%6
11
Dyspnoea3.4%5
12
Nausea3.4%5
13
Injection Site Swelling3.4%5
14
Headache2.8%4
15
Asthenia2.8%4

These are voluntary reports and do not establish that olezarsen caused these reactions.

Report severity

35.2%Serious51 reports
24.8%Hospitalizations36 reports
0.7%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Olezarsen drug interactions

Other drugs that appear in adverse event reports alongside olezarsen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen1.4%2
2
Lomitapide-mesylate0.7%1
3
Tirzepatide0.7%1

Taken alongside

1
Fenofibrate13.8%20
2
Insulin11.0%16
3
Rosuvastatin10.3%15
4
Icosapent-ethyl9.7%14
5
Ondansetron7.6%11
6
Ergocalciferol7.6%11
7
Evolocumab6.9%10
8
Pantoprazole-sodium6.9%10
9
Atorvastatin-calcium5.5%8
10
Lisinopril4.8%7
11
Metformin4.8%7
12
Lidocaine3.4%5
13
Acetaminophen3.4%5
14
Nitroglycerin2.8%4
15
Metoprolol2.8%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports olezarsen side effects

1.4% of olezarsen adverse event reports involve female patients and 0.0% involve male patients. The largest age group is adult at 89%. These figures reflect who reports side effects, not underlying risk.

Sex

Female1.4%
Male0.0%
Unknown98.6%

Age group

< 20.0%
2–110.0%
12–171.1%
18–6488.6%
65+10.2%

What is olezarsen used for

Conditions and purposes for which patients were taking olezarsen when the adverse event was reported.

Blood Cholesterol AbnormalFamilial HypertriglyceridaemiaHyperchylomicronaemiaHypertriglyceridaemiaLipoprotein DeficiencyProduct Used For Unknown Indication

Olezarsen brand names and reporting trend

Olezarsen is sold under the brand name Tryngolza (autoinjector).

Brand names

Tryngolza (autoinjector)2

Quarterly reports (20242025)

20242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking olezarsen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.