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Olaparib Side Effects

The most commonly reported side effects of olaparib include death, malignant neoplasm progression, and nausea, based on 19,466 FDA adverse event reports from 2012 to 2025. 3.3% of reports found the drug to be ineffective.

Olaparib side effects

Percentages show how often each reaction appears relative to total reports for olaparib.

1
Death23.2%4,519
2
Malignant Neoplasm Progression10.1%1,960
3
Nausea8.7%1,694
4
Fatigue8.2%1,599
5
Anaemia7.9%1,535
6
Off Label Use4.5%873
7
Vomiting3.5%683
8
Drug Ineffective3.3%644
9
Diarrhoea3.0%583
10
Asthenia2.8%554
11
Decreased Appetite2.6%505
12
Neuropathy Peripheral2.5%496
13
Disease Progression2.4%475
14
Myelodysplastic Syndrome2.4%464
15
Haemoglobin Decreased2.1%412

These are voluntary reports and do not establish that olaparib caused these reactions.

Report severity

90.5%Serious17,625 reports
18.4%Hospitalizations3,575 reports
29.1%Fatal5,656 reports

Seriousness is determined by the reporter, not by OpenClaim.

Olaparib drug interactions

Other drugs that appear in adverse event reports alongside olaparib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab4.2%810
2
Carboplatin3.9%756
3
Paclitaxel3.4%656
4
Gemcitabine1.4%280
5
Doxorubicin-hydrochloride1.3%250
6
Pembrolizumab1.2%230
7
Abiraterone-acetate1.1%206
8
Temozolomide1.0%192
9
Durvalumab1.0%191
10
Niraparib-tosylate0.8%156
11
Docetaxel0.8%150
12
Cisplatin0.7%132
13
Metoprolol0.6%121
14
Fulvestrant0.6%120
15
Enzalutamide0.6%116

Taken alongside

1
Bevacizumab2.7%516
2
Ondansetron2.1%401
3
Acetaminophen1.9%373
4
Ergocalciferol1.5%291
5
Paclitaxel1.5%283
6
Levothyroxine-sodium1.4%275
7
Carboplatin1.4%273
8
Amlodipine1.2%237
9
Atorvastatin-calcium1.1%220
10
Aspirin1.1%220
11
Omeprazole1.1%218
12
Pantoprazole-sodium1.1%214
13
Oxycodone1.1%212
14
Dexamethasone1.0%201
15
Gabapentin1.0%190

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports olaparib side effects

70.7% of olaparib adverse event reports involve female patients and 20.3% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female70.7%
Male20.3%
Unknown9.0%

Age group

< 2<0.1%
2–110.1%
12–170.2%
18–6454.3%
65+45.4%

What is olaparib used for

Conditions and purposes for which patients were taking olaparib when the adverse event was reported.

Abdominal NeoplasmAbdominal PainAcinar Cell Carcinoma Of PancreasAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma Of ColonAdenocarcinoma PancreasAdenosquamous Cell Lung CancerAdrenocortical CarcinomaAdverse Drug ReactionAppendix CancerAscitesAstrocytoma MalignantAcinar Cell Carcinoma Of PancreasAcquired Gene Mutation

Showing 15 of 569 indications

Olaparib brand names and reporting trend

Olaparib is sold under the brand name Olaparib.

Brand names

Olaparib7,077

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking olaparib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.