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Ocrelizumab Side Effects

The most commonly reported side effects of ocrelizumab include covid-19, fatigue, and urinary tract infection, based on 59,857 FDA adverse event reports from 2007 to 2025. 3.9% of reports found the drug to be ineffective.

Ocrelizumab side effects

Percentages show how often each reaction appears relative to total reports for ocrelizumab.

1
Covid-1919.3%11,530
2
Fatigue10.2%6,078
3
Urinary Tract Infection6.2%3,723
4
Headache5.3%3,201
5
Multiple Sclerosis4.8%2,896
6
Asthenia4.5%2,667
7
Gait Disturbance4.4%2,646
8
Multiple Sclerosis Relapse4.3%2,595
9
Nasopharyngitis4.2%2,527
10
Pain4.1%2,480
11
Fall4.1%2,472
12
Pneumonia4.0%2,391
13
Off Label Use4.0%2,381
14
Drug Ineffective3.9%2,363
15
Infusion Related Reaction3.6%2,156

These are voluntary reports and do not establish that ocrelizumab caused these reactions.

Report severity

49.6%Serious29,667 reports
18.3%Hospitalizations10,925 reports
2.5%Fatal1,474 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ocrelizumab drug interactions

Other drugs that appear in adverse event reports alongside ocrelizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfampridine1.7%1,015
2
Rituximab1.3%801
3
Methylprednisolone0.9%544
4
Natalizumab0.8%485
5
Dimethyl0.7%428
6
Diphenhydramine0.7%416
7
Clonazepam0.6%347
8
Fingolimod0.5%296
9
Glatiramer-acetate0.5%271
10
Teriflunomide0.4%260
11
Interferon0.4%251
12
Ofatumumab0.4%249
13
Hydrocortisone0.4%232
14
Diazepam0.4%210
15
Gabapentin0.3%184

Taken alongside

1
Baclofen6.5%3,913
2
Acetaminophen6.2%3,735
3
Gabapentin4.9%2,943
4
Methylprednisolone4.6%2,777
5
Ergocalciferol4.6%2,773
6
Diphenhydramine3.6%2,167
7
Dalfampridine3.4%2,023
8
Levothyroxine-sodium2.9%1,733
9
Ibuprofen2.6%1,572
10
Cholecalciferol2.4%1,418
11
Pregabalin2.3%1,382
12
Duloxetine-hydrochloride2.1%1,251
13
Aspirin1.9%1,142
14
Pantoprazole-sodium1.9%1,141
15
Tizanidine-hydrochloride1.8%1,093

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ocrelizumab side effects

63.5% of ocrelizumab adverse event reports involve female patients and 23.8% involve male patients. The largest age group is adult at 90%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.5%
Male23.8%
Unknown12.7%

Age group

< 20.4%
2–11<0.1%
12–170.2%
18–6490.3%
65+9.1%

What is ocrelizumab used for

Conditions and purposes for which patients were taking ocrelizumab when the adverse event was reported.

Acute Disseminated EncephalomyelitisAmnesiaArterial Stent InsertionAsthmaAtrial FibrillationAutoimmune DisorderAcute Myocardial InfarctionAdverse Drug ReactionAmyotrophic Lateral SclerosisAnkylosing SpondylitisAnti-neutrophil Cytoplasmic Antibody Positive VasculitisAntisynthetase SyndromeAnxiety DisorderArterial Stent InsertionAtaxia

Showing 15 of 227 indications

Ocrelizumab brand names and reporting trend

Ocrelizumab is sold under the brand name Ocrevus.

Brand names

Ocrevus15,470

Quarterly reports (20072025)

2007201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ocrelizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.