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Obinutuzumab Side Effects

The most commonly reported side effects of obinutuzumab include off label use, neutropenia, and covid-19, based on 16,353 FDA adverse event reports from 2011 to 2025.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: VenetoclaxDrug interactions ↓54% of Reports Are ElderlyDemographics ↓

Obinutuzumab side effects

Percentages show how often each reaction appears relative to total reports for obinutuzumab.

1
Off Label Use10.9%1,786
2
Neutropenia8.5%1,398
3
Covid-196.6%1,079
4
Febrile Neutropenia6.4%1,043
5
Pyrexia6.2%1,021
6
Thrombocytopenia5.8%952
7
Disease Progression5.5%892
8
Infusion Related Reaction5.4%879
9
Pneumonia4.8%780
10
Anaemia4.3%707
11
Atrial Fibrillation3.6%594
12
Infection3.6%582
13
Nausea3.3%542
14
Death3.3%538
15
Dyspnoea3.2%529

These are voluntary reports and do not establish that obinutuzumab caused these reactions.

Report severity

84.5%Serious13,812 reports
37.7%Hospitalizations6,160 reports
13.5%Fatal2,214 reports

Seriousness is determined by the reporter, not by OpenClaim.

Obinutuzumab drug interactions

Other drugs that appear in adverse event reports alongside obinutuzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Venetoclax20.9%3,424
2
Rituximab17.3%2,822
3
Bendamustine-hydrochloride15.8%2,584
4
Cyclophosphamide14.3%2,335
5
Vincristine-sulfate12.8%2,087
6
Doxorubicin-hydrochloride11.8%1,925
7
Ibrutinib11.2%1,832
8
Prednisone10.8%1,770
9
Etoposide5.5%893
10
Lenalidomide5.2%849
11
Dexamethasone4.8%782
12
Prednisolone4.4%726
13
Chlorambucil4.3%709
14
Ifosfamide4.0%654
15
Glofitamab-gxbm3.8%629

Taken alongside

1
Acetaminophen10.7%1,753
2
Allopurinol9.6%1,567
3
Dexamethasone6.5%1,069
4
Acyclovir6.5%1,065
5
Sulfamethoxazole5.7%927
6
Bendamustine-hydrochloride5.3%868
7
Trimethoprim5.0%812
8
Prednisone4.8%793
9
Ondansetron4.2%680
10
Cyclophosphamide4.0%652
11
Methylprednisolone3.8%629
12
Aspirin3.6%589
13
Omeprazole3.5%567
14
Diphenhydramine3.2%517
15
Pantoprazole-sodium3.2%516

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports obinutuzumab side effects

33.5% of obinutuzumab adverse event reports involve female patients and 49.2% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.5%
Male49.2%
Unknown17.3%

Age group

< 2<0.1%
2–110.9%
12–170.7%
18–6444.7%
65+53.7%

What is obinutuzumab used for

Conditions and purposes for which patients were taking obinutuzumab when the adverse event was reported.

5q Minus SyndromeAcute LeukaemiaAcute Lymphocytic LeukaemiaAdjuvant TherapyAgranulocytosisAntiviral ProphylaxisAplastic AnaemiaAutoimmune Haemolytic AnaemiaAbdominal NeoplasmAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RefractoryAcute Myeloid LeukaemiaAcute Respiratory Distress SyndromeAdjuvant TherapyAdverse Drug Reaction

Showing 15 of 432 indications

Obinutuzumab brand names and reporting trend

Obinutuzumab is sold under the brand name Gazyva.

Brand names

Gazyva16,408

Quarterly reports (2011–2025)

20112016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking obinutuzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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