OpenClaim

Nusinersen Side Effects

The most commonly reported side effects of nusinersen include headache, post lumbar puncture syndrome, and pyrexia, based on 7,314 FDA adverse event reports from 2016 to 2025. 1.9% of reports found the drug to be ineffective.

#1 Reported: HeadacheAll side effects ↓Top Co-Medication: RisdiplamDrug interactions ↓36% of Reports Are AdultDemographics ↓

Nusinersen side effects

Percentages show how often each reaction appears relative to total reports for nusinersen.

1
Headache7.1%517
2
Post Lumbar Puncture Syndrome6.9%502
3
Pyrexia5.3%389
4
Procedural Pain4.9%359
5
Pneumonia4.8%354
6
Death4.4%322
7
Vomiting4.1%300
8
Asthenia3.8%278
9
Back Pain3.3%239
10
Scoliosis3.0%221
11
Fatigue2.9%209
12
Malaise2.3%168
13
Fall2.3%166
14
Nausea2.2%161
15
Nasopharyngitis2.1%155

These are voluntary reports and do not establish that nusinersen caused these reactions.

Report severity

50.3%Serious3,679 reports
31.2%Hospitalizations2,285 reports
10.6%Fatal772 reports

Seriousness is determined by the reporter, not by OpenClaim.

Nusinersen drug interactions

Other drugs that appear in adverse event reports alongside nusinersen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Risdiplam1.7%124
2
Prednisolone0.2%13
3
Clindamycin<0.1%7
4
Estropipate<0.1%7
5
Metoprolol<0.1%7
6
Ramipril<0.1%6
7
Palivizumab<0.1%5
8
Acetaminophen<0.1%5
9
Vitamin-k<0.1%5
10
Propofol<0.1%4
11
Zoledronic-acid<0.1%4
12
Midazolam<0.1%4
13
Ketamine-hydrochloride<0.1%4
14
Albuterol<0.1%3
15
Metronidazole<0.1%3

Taken alongside

1
Albuterol3.0%217
2
Ergocalciferol2.4%178
3
Acetaminophen1.4%101
4
Polyethylene-glycol-33501.1%83
5
Lidocaine1.0%74
6
Omeprazole1.0%72
7
Sodium-chloride0.9%63
8
Risdiplam0.9%63
9
Budesonide0.8%59
10
Ibuprofen0.7%51
11
Prednisolone0.7%49
12
Fluticasone0.6%45
13
Cetirizine-hydrochloride0.6%43
14
Famotidine0.5%40
15
Ranitidine0.5%38

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports nusinersen side effects

45.8% of nusinersen adverse event reports involve female patients and 44.6% involve male patients. The largest age group is adult at 36%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.8%
Male44.6%
Unknown9.6%

Age group

< 216.0%
2–1133.7%
12–1713.1%
18–6435.7%
65+1.6%

What is nusinersen used for

Conditions and purposes for which patients were taking nusinersen when the adverse event was reported.

Amyotrophic Lateral SclerosisAccidental Exposure To ProductAdverse Drug ReactionMuscle AtrophyMaternal Exposure Timing UnspecifiedOsteoporosisProduct Used For Unknown IndicationProduct Used For Unknown IndicationSpinal Muscular AtrophySpinal Muscular Atrophy

Nusinersen brand names and reporting trend

Nusinersen is sold under the brand name Spinraza.

Brand names

Spinraza312

Quarterly reports (2016–2025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking nusinersen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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